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Microfluidic electrocapture technology in protein and peptide analysis
(2004-05-19)
After sequencing the genomes of several organisms, science in the postgenomic era now aims at a thorough study of the proteins present in a given tissue or organism. Since this task requires an enormous analytical effort, ...
Studies in sporadic inclusion body myositis
(2003-05-15)
Aims: The general aims of the present study were to increase the understanding of the disease process in s-lBM by analysing the cytoskeletal structure in muscle fibres and their regeneration potential; and also to evaluate ...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
Microfluidic analysis and parallel confocal detection of single molecules
(2003-09-12)
) was utilized to investigate hydrodynamic pressure driven flow in microchannels with a cross section of 50 x 50 µm2. The flow itself, was detected non-altered or noninvasively, since only tiny (a couple of nanometer in size) dye-molecules were entrained...
Physical performance tests and spinal pain : assessing impairments and activity limitations
(2002-05-09)
Background: Long-term spinal pain is a common health problem, often leading to disabilities. There is still no general agreement on what measures to use for evaluating disability in people with spinal pain. Performance-based ...
Theoretical prediction of ionisation properties of proteins
(2003-05-20)
of ensembles of protein structures alternative conformers in X-ray structures, NMR models, molecular dynamics simulation. Second, the theoretical description of the pKa calculations based on continuum electrostatic model was generalized in order to account...
Insulin resistance, genetic variation and cytokines : associations to myocardial infarction risk
(2003-10-17)
Insulin resistance, inflammation and associated genes are considered as factors of potential importance for the pathogenesis of cardiovascular diseases, but their relationship to myocardial infarction (MI) and associated ...
Development of intimal hyperplasia in transplant arteriosclerosis
(2003-01-24)
Vascular disease is the main cause of disability and mortality in the western world and the major limiting factor for long- term survival of transplanted organs. Occlusive vascular lesions lead to ischemia and structural ...
Method development for analysis of 8-oxodG as a biomarker for oxidative stress
(2001-11-22)
Oxidative damage to DNA gives oxidation of DNA bases and strand breaks
that can cause mutations leading to cancer. Various forms of agents are
capable of oxidising DNA in vivo including peroxides, singlet oxygen and
UV- ...
Extrahepatic cytochrome P450s : relation to cancer susceptibility
(2003-09-19)
Cytochrome P450 (CYP) enzymes in extrahepatic tissues may play important roles in regulating the capacity of individual cells to metabolize environmental carcinogens and hormones. In this thesis, we characterized the ...