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Changes in mitogen-activated protein kinase phosphorylation and inorganic phosphate induced by skeletal muscle contraction
(2002-10-04)
Skeletal muscles adjust to the level of contractile activity by different biochemical alterations. Contraction is a multifactorial stimulus with short-term metabolic effects and long-term responses due to changes in protein ...
Patient-related aspects on WAD
(2004-05-21)
Forces acting on the neck at a motor vehicle accident (MVA) can result in soft tissue injuries, commonly considered as "whiplash injuries", with different clinical manifestations, Whiplash Associated Disorders (WAD). The ...
The role of Malassezia in the pathogenesis of atopic eczema/dermatitis syndrome
(2002-01-25)
Atopic eczema/dermatitis syndrome (AEDS) is a chronically relapsing skin
disease, which is often associated with elevated levels of serum lgE. The
immunopathology of AEDS is at present unclear, but it is known that
lymphocytes ...
Molecular mechanisms involved in the growth of human uterine leiomyomas
(2002-11-14)
Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which ...
Characterization and expression of subtypes of nicotinic receptors in brain and adrenal medulla : with focus on development, Alzheimer's disease and transgenic animal models
(2003-08-22)
The cholinergic nicotinic receptors (nAChRs) seem to play an important role in numerous important physiological processes in brain as well as peripheral tissues of man. In first trimester human brain mRNA levels for the ...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear ...
Local recurrence after breast conserving surgery in breast cancer
(2002-08-30)
The general aim of this thesis was to gain increased insight into the problem of local recurrences after breast conserving surgery for breast cancer. In a population-based cohort of 4,694 women with invasive breast cancer, ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Tissue prostatic specific antigen (T-PSA) : a way to predict and understand the development of prostate cancer
(2001-09-21)
Prostate cancer (CaP) is the most prevalent malignancy among men in
Sweden. One major problem associated with CaP is the choice of treatment
since the disease may develop very differently from patient to patient.
Many ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...