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Galanin and Leu-enkephalin in the rat : with special reference to adjuvant arthritis
(2004-05-20)
In these studies, the tissue and cellular distribution of Galanin and
Leu-enkephalin were demonstrated in normal bone and joints. Furthermore,
tissue levels of Galanin and Leuenkephalin were also studied in the
ankles ...
Health risk assessment of dioxin-like compounds in complex samples
(2003-10-10)
There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause ...
NF-kB in epidermal signal transduction and tumor development
(2002-11-15)
The transcription factor NF-kappaB has been extensively studied since its discovery. NFkappaB has been shown to be invoved in many cellular processes in many different cell types. However, its functions in skin physiology ...
T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses
(2002-11-15)
Immunodominance is a process in which the immune response focuses on one
or a few of all potential epitopes that exists within an antigen. The
mechanisms for immunodominance have not yet been determined. The work
described ...
Glucocorticoids in the development and homeostasis of T lymphocytes
(2002-05-24)
Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate ...
Regulation of dioxin receptor function by the Hsp90 chaperone complex
(2002-03-22)
In mammals the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors includes the dioxin receptor which is a ligand-dependent transcription factor which mediates biological effects of environmental pollutants such as 2,3,7...
On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha
(2003-11-07)
Anti-cancer drugs act primarily by inducing apoptosis. However, knowledge of how various substances induce apoptosis is still incomplete, and so is the basis for the great variation in cellular sensitivity to cytotoxic ...
Factors of importance for radiosensitivity of tonsillar carcinoma
(2002-05-24)
Radiotherapy (RT) alone or in combination with surgery is the only curative treatment of tonsillar carcinoma (TC). As distant metastases are rare the loco-regional control is the most important factor determining survival. ...
A functional genomics approach to study prostate disorders
(2003-09-12)
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized ...
Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis
(2004-02-06)
The family of VEGF/PDGF growth factors and their receptors are important regulators of tumorigenesis and angiogenesis. VEGFs have been shown to play important roles in development of both blood and lymphatic vessels by ...