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Regulation of mitochondrial transcription and mtDNA copy number in mammals
(2003-05-02)
Functional mitochondria are essential for wellbeing of the cell and the whole organism. Gene expression from the mitochondrial genome (mtDNA) is indispensable for oxidative phosphorylation, but also for the replication of ...
Long-term outcome of patients with rheumatoid arthritis and systemic lupus erythematosus with special reference to cardiovascular disease
(2004-01-22)
The aim of this thesis was to assess the long-term prognosis in terms of mortality, especially from cardiovascular disease, in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). By using the ...
Molecular complexities of patched signaling in cancer development
(2004-05-21)
Basal Cell Cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. BCCs mainly occur as sporadic tumors but can ...
Hemostasis in middle-aged women with coronary heart disease
(2004-08-20)
Inflammation and hemostasis play important roles in atherosclerotic disease. Chronic low-grade inflammation contributes to plaque vulnerability and rupture, and the subsequent thrombus formation is identified as the key ...
Experienced physical functioning and effects of resistance training in patients with chronic kidney disease
(2004-04-15)
Physical fitness declines as chronic kidney disease progresses, and is approximately 50% of the expected norm when starting dialysis therapy This means that physical fitness in these patients is so reduced that it impinge ...
Determinants of ligand-induced nuclear receptor activation
(2004-05-13)
The nuclear receptors (NRs) constitute a highly conserved superfamily of transcription factors restricted to metazoans. In general, these receptors are regulated by small lipophilic molecules such as steroids, thyroid ...
Heparan sulfate dependent sequestration during Plasmodium falciparum malaria
(2004-09-03)
Plasmodium falciparum infected erythrocytes are able to bind to the microvascular endothelium (cytoadherence), and to uninfected erythrocytes (rosetting) that lead to excessive sequestration of the parasites. This causes ...
A concept for treatment of sports related knee injuries
(2004-04-02)
The aim of the present thesis was, to evaluate local anaesthesia as ananaesthetic technique when performing knee arthroscopies, from a clinicaland economical point of view, and to describe the total costs for surgeryof ...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
Prader Willi Syndrome (PWS) is a complex genetic disorder characterized by muscular hypotonia, hyperphagia, obesity and behavioural problems. Partial growth hormone (GH) deficiency and hypogonadism are common. Results of ...
Method development for analysis of 8-oxodG as a biomarker for oxidative stress
(2001-11-22)
-irradiation. Oxidation of DNA bases occurs mainly at dG,
giving stable DNA adducts such as 8-oxodG and FapydG.
The use of 8-oxodG as a biomarker (expressed as the ratio 8-oxodG/dG)
requires well- controlled workup conditions because 8-oxodG can be formed
during...