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Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology
(2002-01-25)
enzyme variant originates from the CYP2C9*1 allele, whereas CYP2C9*2 and CYP2C9*3 code for enzymes with amino acid substitutions R144C and 1359L, respectively. There is accumulating evidence that this genetic polymorphism give rise to clinically important...
Sample preparation and mass spectrometry in proteome studies
(2004-05-07)
on the IMAC CD down to a level of I pmol protein applied to SDS PAGE. Applied to non-characterized samples, the method identified two novel phosphorylation sites, Thr 735 and Ser 737, in the ligand-binding domain of the human mineralocorticoid receptor...
Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment
(2003-12-26)
of CMV-related complications after SCT.
In a study of 584 consecutive allogeneic SCT patients, the overall
probability for CMVdisease was 8.9%, and the risk for death in
CMV-disease 5.7%. The risk varied depending on CMV-serologies in donors...
Bioactive peptides and proteins in disease
(2004-05-17)
Regulatory peptides and marker proteins are important to study in order to understand disease mechanisms. This applies of course also to our common diseases where all relationships are not yet known. Cancer and diabetes ...
Appetitive and consummatory ingestive behavior : role of taste, dopamine and NPY
(2001-11-23)
The present thesis has examined the role of taste, dopamine and
neuropeptide Y (NPY) in the regulation of the two phases of ingestive
behavior: appetitive (approaching and handling of food) and consummatory
ingestive ...
Strategies of gene and immune therapy for tumors and viral diseases
(2003-04-04)
-mediated expression of small interfering RNAs (siRNA) against either endogenous transcripts for the primary HIV-1 coreceptor, CCR5, or viral transcripts for the Rev gene of HIV-1, we were able to inhibit efficiently both viral infection and replication, respectively...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Retinoids in experimental neuroblastoma therapy
(2003-01-24)
Retinoids are analogues of vitamin A, with documented activity against various malignant cell types. Neuroblastoma is a childhood tumour of the sympathetic nervous system that shows a complex clinical and biological ...
Resistance mechanisms for nucleoside analogues : with focus on metabolism and apoptosis
(2002-11-01)
'-nucleotidase (5'-NT). The RQPCR method was compared to semi-quantitative PCR and enzyme activity measurements and tested with samples from pediatric patients with acute lymphocytic or myeloid leukemias, and was shown to be a convenient and reliable tool...
A study of b-secretase cleaved Alzheimer amyloid precursor protein
(2002-04-05)
Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). ...