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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Molecular regulation of microsomal triglyceride transfer protein gene, MTP : functional genetic studies in relation to cardiovascular disease
(2004-11-26)
lipoprotein concentrations in plasma, and the lipid metabolism of the
heart.
In Paper I, we show that two promoter polymorphisms, -493G>T and -164T>C,
and one missense polymorphism in exon 3, I>T128, are in almost complete
linkage disequilibrium. Healthy 50...
Exhaled nitric oxide in schoolchildren with asthma
(2004-11-19)
Background: The fraction of nitric oxide in exhaled air (FENO) is believed to reflect the degree of allergic inflammation present in the lower airways. The diffusing capacity of NO in the airways (DawNO) and the concentration ...
Foregut motility disorders : a clinical and experimental study
(2004-08-13)
Objective: To investigate some clinical aspects and treatment modalities
of foregut motility disorders and to experimentally explore some
mechanisms involved. Special emphasis has been put on elucidating and
evaluating ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
is in strong linkage with -318C/T and is more frequently present in MG patients with thymoma. MG patients carrying -318C showed significantly decreased expression of CTLA-4 mRNA in non-stimulated cells. In the present study, the relationship of the expression...
Chronic infection with chlamydia pneumoniae in COPD and lung cancer
(2005-09-16)
. The prevalence of Cpn IgG antibody titres of >1/512 was 57% in male LC patients compared to 27% in male 70 year olds and 17% in male blood donors. The prevalence of Cpn lgA antibody titres >1/64 was 69% for male LC patients compared to 25% and 20% for respective...
Catalytic mechanisms and evolution of leukotriene A4 hydrolyse
(2006-11-10)
of chemical mediators, which by different means control, maintain and resolve the process. One group of such mediators is the leukotrienes, among which LTB4 is found. LTB4 has several immunomodulating properties and mainly acts by recruiting leukocytes...