Search
Now showing items 1-10 of 404
Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Influence of maternal allergy on the intra uterine environment and on immune functions of the neonate
(2005-02-25)
The prevalence of IgE mediated allergic diseases has drastically increased during the past few decades and there is no satisfactory explanation. A family history of allergic disease is clearly a strong risk factor, bin in ...
Maternal morbidity in Uganda : studies on life-threatening pregnancy complications in low-income settings
(2004-11-25)
Introduction: Life-threatening complications in pregnancy rarely achieves
public health prominence in the same way as maternal mortality partly
because they represent a wide spectrum of conditions. The improved level
of ...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities.
In the first part of this thesis we could establish and confirm ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties.
Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high ...
Genetic association analysis of overlapping biological pathways in cardiovascular and Alzheimer disease
(2006-05-26)
To gain insight into the importance of the genome for diseases, sequencing and genotyping efforts aim to identify the consequences of genetic variation on both a functional and population level. The task involves the ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
B. subtilis, A. aeolicus and a designed mutant LS from A. aeolicus (structure determined by cryo-EM in manuscript IV) were studied using small angle x-ray scattering (SAXS) and cryo-EM. The results indicate that multiple assembly states are a general...
Child health promotion : analyses of activities and policy processes in 25 Swedish municipalities
(2005-09-30)
The Swedish municipalities are important actors that offer appropriate
environments for healthpromoting activities directed at children and
adolescents. Enhanced understanding on how such activities develop is
needed ...
The analgesic mechanisms of buprenorphine
(2006-01-13)
Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic ...
Physical activity in rheumatoid arthritis
(2006-04-28)
Physical activity confers health benefits in the general population and should also be applied to people with rheumatoid arthritis (RA). However, there is a need for more research in this area. The aim of this thesis was ...