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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel ...
Therapeutic myocardial angiogenesis and its pharmacological modulation
(2005-09-30)
growth. Overexpressed growth factors (V, A, and V+A) stimulated the mouse VEGF-Ang system whereas placebo plasmid had no such effects. Phosphorylation of antiapoptotic Akt and its downstream effector GSK3-alpha/beta were lower during myocardial ischemia...
Nutritional status and cognitive function in frail elderly subjects
(2004-08-13)
weight gain of 3.4 ±11.2 kg (p=0.00 1) 6 months later, that was not seen in the control group. The weight gain was not related to an improvement in ADL capacity or cognitive function (MMSE). A BMI <23 was noticed in more than half of 231 patients admitted...
Progression of periodontitis and influence of periodontal bacteria on release of inflammatory markers in Swedish adults
(2005-12-23)
Periodontitis is a common infectious disease worldwide. An estimated 15-35% of the adult population in industrialized countries suffers from this multifactorial disease. The percentage of people affected by periodontal ...
Development of AIDS associated and endemic Kaposi sarcoma : HHV-8/KSHV viral load in cutaneous and oral tumor cells
(2006-09-05)
(paper 111), we have not found significant higher HHV-8 load in AKS compared to EKS in accordance with the immunohistochemistry findings and consistent with the notion of basically similar pathogenic mechanisms for these clinically distinct lesions. HHV-8...
T cell responses and NK cell function in experimental autoimmune diabetes
(2004-11-12)
The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent autoimmune diseases. However, genetic as well as environmental factors can increase the risk of breaking self tolerance. ...
Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
(2004-11-26)
-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an alpha-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide...
Synthetic studies of marine indole alkaloids and related systems
(2005-11-25)
coupling with 6-bromotryptophan methyl ester, as in the case of 8,9-dihydrobarettin, or as a phosphonate derivative in a Homer-Wadsworth-Emmons reaction with 6-bromoindole-3carboxaldehyde, as in the key step in the synthesis of barettin. Both barettin and 8...
The insulin-like growth factor system : effects of circulating proteases
(2005-08-18)
factors. In scrum most IGF circulate in a ternary complex with IGF-binding protein-3 (IGFBP-3) and the acid labile subunit (ALS). The affinity between IGF and IGFBP-3 exceeds that between IGF and the type 1 IGF receptor demonstrating that most...
Skin cancer as seen by electrical impedance
(2004-11-05)
This thesis describes the relation between skin cancer and electrical impedance. On the cellular level, electrical impedance measured at clinically relevant frequencies is affected by e.g. membrane structure and orientation, ...