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Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology
(2006-09-22)
plaques, where it colocalized with macrophages, endothelial cells, and smooth muscle cells (SMC). Human coronary artery SMC exposed to either the LTB4 Or the BLT1 partial agonist U75302 exhibited increase of whole-cell ion currents indicating...
Characterization of toxicological effects of a novel in vivo benzo[a]pyrene metabolite in colonic cells
(2004-09-01)
[d]anthracene-3,4dicarboxylic acid (ABADA) exhibits any toxicological activity in cultured colonic cells. ABADA was shown to have weak mutagenic activity in Salmonella typhimurium strain TA 102 (detects oxidative mutagens). The cytotoxicity of ABADA seen in HCT...
Molecular basis of estrogen receptor antagonism
(2006-01-27)
Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined ...
Psychosocial situation of parents of children with congenital heart disease
(2004-12-31)
and PHC were 4-26% and 3-25% respectively. In addition, 13% of PCCHD, 12% of PCOD and 5% of PHC were at moderate/high risk of suicide ideation. Further, PCCHD reported lower quality of life than PHC. In contrast, the parental groups did not differ...
A prospective study of mental health among mass-evacuated Kosovo Albanians
(2006-02-17)
Mental health outcomes among traumatised refugees have been of interest to researchers for decades. However, so far little is known about specific refugee groups such as asylum seekers and temporary mass-evacuees although ...
The impact of protein modification on immunogenicity and arthritogenicity
(2005-09-09)
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 1% of the Western world population. There are several theories regarding the etiopathogenesis.
The aim of this thesis was to study, ...
The impact of estrogens on leukocyte function in remodeling of extracellular matrix
(2005-11-23)
ERalpha agonist PPT (4,4',4"-(4-Propyl-[lII]-pyrazole-1,3,5 -triyl)trisphenol) and the selective ERbeta agonist DPN (2,3bis(4hydroxyphenyl)-proprionitrile) on gene expression profiles in a rat animal model. This study reports the identification of genes...
Nicotinic transmission and drugs in anesthesia : neuromuscular blocking agents and propofol : consequences for carotid body function
(2006-02-17)
The carotid body is the global oxygen sensor of the human body. Acute hypoxia elicits instant hyperventilation mediated from the carotid body type 1 cells, where nicotinic transmission is a key component in oxygen sensing ...
Arthritogenic and immunogenic properties of modified autoantigens
(2005-03-22)
arthritogenicity. Furthermore, we were able to demonstrate that citrullination of synovial proteins as well as expression of PAD4 were consequences of, and correlated with, the degree of synovitis. Each of these modifications has been suggested to occur at a site...
The influence of psychosocial stress, socioeconomic differences and coffee consumption in the etiology of type 2 diabetes
(2004-12-24)
these associations. Moreover, these variables were not obviously related with type 2 diabetes in men, nor with IGT in men or in women.
Middle and low SEP were associated with type 2 diabetes in both men (RR=2.4, CI: 1.0- and RR=2.9, CI:1.5-5.7, respectively...