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Maternal deprivation and mood stabilizing drugs : effects on rat brain NPY
(2002-10-04)
of the hippocampus and the prevention of a kindling-induced downregulation of Y1-, and Y5-like receptors in the dentate gyrus and Y2-like receptors in the CA3 area of the hippocampus. In contrast, none of these parameters were affected by levetiracetam in normal rats...
Lower limb ischemia in women
(2004-02-27)
Arteriosclerosis is a general disease affecting different parts of the arterial system. In coronary heart disease (CHD) women have different risk factors, symptoms, indication for treatment, interpretation of diagnostic ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
The human placenta : an angiographic study
(2003-04-25)
separate vessel in 112 placentas (85 %), a fenestration in 6 (5%) and a fusion in 3 (2%). In 10 the anastomosis was absent, in five of these due to a single umbilical artery. The anastomosis was wide in placentas in which the relative area supplied by each...
Malignant mesothelioma : an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
(2002-04-17)
Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they ...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
found that Tec family
kinases bind to caveolin-1, a major structural component of caveolae
(rafts or microdomains) located in the plasma membrane. Finally, we
demonstrate that Cbl acts as an E3-ubiquitin ligase for Btk and that
ubiquitinated Btk...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...
Cellular immunity and inflammation in atherosclerosis
(2001-11-09)
Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the ...
Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis
(2004-05-06)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in demyelination, axonal loss and neurological deficits. The aetiology is unknown, however, immunopathological events, ...