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Regeneration of the antioxidant ubiquinol by flavoenzymes and the role of antioxidant defence in experimental hepatocarcinogenesis
(2002-05-24)
In the environment, to which we have adapted and thrive, we are constantly exposed to reactive molecules with the potential to cause intracellular damage and cellular malfunction. One of the molecules that is transformed ...
Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice
(2002-02-08)
detected. The upregulation of nAChRs in these transgenic mice probably reflect compensatory mechanisms in response to A-beta burden. No alterations of the binding sites of nAChR subtypes were observed in APPSWE /PS 1 transgenic mice, despite elevated levels...
Human truncated thioredoxin (Trx80) as a novel mitogenic cytokine for white blood cells
(2001-11-27)
54 and CD86 measured by flow cytometry. Moreover, Trx80 induced a Th1 response in T cells in PBMC cultures. By ELISA and intracellular flow cytometry we found that Trx80 alone stimulated the expression of the Th 1 inducer cytokine IL- 12 from CD40...
Risk characterization of familial cancer using the Swedish family-cancer database with a special reference to breast cancer
(2003-11-07)
the usual risk when one of the parents had cancer, if both parents had cancer, the risk was 1.3-1.4 times higher. When offspring cancer risk was analyzed by index cancer, same as in parent, the risk elevated to 2-3 times for many cancer sites like colorectum...
The human placenta : an angiographic study
(2003-04-25)
to be an applicable model. In 22 placentas from uncomplicated pregnancies with normal FVW, the scaling properties were as good as for constructed perfect fractals. The fractal dimension was in mean 1.864. The results suggest that there is an underlying regular...
Extrahepatic cytochrome P450s : relation to cancer susceptibility
(2003-09-19)
in 15 samples and found enzymes involved in the metabolism of environmental carcinogens, steroid hormones and drugs. A large interindividual variation in the expression of CYP1A1, 2A6, 2B6, 2D6 and 3A were shown whereas CYP1B1, 2C, 2E 1, 4A and 19...
Carbon dioxide de-airing in cardiac surgery
(2004-01-09)
patient groups did not differ in clinical parameters. The median number of microemboli registered during the whole study period was 161 in the C02 group versus 723 in the control-group (p<0.001). Corresponding numbers for the left atrium were 69 versus 340...
Mesothelial differentiation, mesothelioma and tumor markers in serous cavities
(2003-05-23)
Mesothelial cells covering the serous membranes are of mesodermal origin although they acquire several characteristics of epithelial cells. The cytological and histological diagnosis of malignant tumors in serous cavities ...
Development of a new PNA analogue as a potential antisense drug and tool for life-science studies
(2004-05-13)
The work described in this thesis focuses on applying synthetic organic chemistry methods (supported by modem synthesizers and analytical techniques) for the preparation of peptides and modified nucleic acids in order to ...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
-99 according to an extensive investigational protocol. A presumptive explanation of the stillbirth was established in 91% of the cases. The most common factors associated with intrauterine fetal death could be identified as infections (24%), placental...