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Protein modification with hydrophobic prenyl groups in malignant cells
(2001-10-19)
Mevalonate (MVA) is the key intermediate in the isoprene synthetic
pathway leading to the formation of a number of biologically important
lipid molecules. It is well known that inhibition of MVA synthesis blocks
the cell ...
Cutaneous malignant melanoma aspects of prognostic factors and time : trends in a Swedish population
(2002-11-01)
One of the aims of this thesis was to assess the possible impact of primary and secondary preventive activities in the population of Stockholm-Gotland with the objective to reduce the incidence and mortality from cutaneous ...
Uveal melanoma : cytogenetics, molecular biology and tumor immunology
(2002-09-13)
Uveal melanoma is the most common primary intraocular malignancy. The
metastatic spread is hematogenous and exclusively to the liver. Although
eye-sparing treatments are used more frequently the tumor-related
mortality ...
Cloning and characterization of a p-53-inducible gene, WIG-1
(2001-11-27)
Elucidating the mechanisms by which p53 inhibits tumor growth is a central issue in cancer research, as the TP53 gene is mutated in over half of all human cancers. Lack of functional p53 also contributes to the resistance ...
Human papillomavirus in tonsillar cancer
(2002-11-01)
Human papillomviruses (HPVs) are known to be causative agents for the development of cervical carcinoma. To what extent HPV is associated with head and neck cancer remains to be clarified, but an association to tonsillar ...
The role of angiomotin in angiogenesis
(2003-12-26)
Angiogenesis plays key roles during embryonic development, female reproduction and wound repair. Angiogenesis, the formation of new blood vessels from of pre-existing capillaries, is a process tightly regulated by a balance ...
Horizontal gene transfer by uptake of apoptotic bodies
(2003-11-14)
In adults as well as during embryogenesis, apoptosis plays a key role in the elimination of cells in multicellular organisms. Apoptosis is important for the maintenance of tissue homeostasis. It is also of importance in ...
Factors of importance for radiosensitivity of tonsillar carcinoma
(2002-05-24)
Radiotherapy (RT) alone or in combination with surgery is the only curative treatment of tonsillar carcinoma (TC). As distant metastases are rare the loco-regional control is the most important factor determining survival. ...
Skin cancer prevention : readiness to change sun-related behaviours
(2004-04-02)
The general aim of this thesis was to collect data relevant for skin
cancer prevention and to investigate the applicability of the
Transtheoretical Model for sun-related behaviour. Also, to assess the
readiness to change ...
On the pro-apoptotic mechanisms of the antitumor drugs doxorubicin and interferon-alpha
(2003-11-07)
Anti-cancer drugs act primarily by inducing apoptosis. However, knowledge of how various substances induce apoptosis is still incomplete, and so is the basis for the great variation in cellular sensitivity to cytotoxic ...