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Toxin production in clostridium difficile
(2004-05-20)
Clostridium difficile is a is a Gram potential human pathogen. It causing symptoms ranging from mild C. difficile associated diarrhea (CDAD) to severe inflammation of the colon including pseudomembranous colitis and fulminant ...
Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants
(2003-11-24)
is found in all organisms and consists of thioredoxin (TXN), thioredoxin reductase (TXNRD) and NADPH and it participates in many different types of reactions. Mammalian TXNRD1 is a selenoprotein containing a redox active selenocysteine residue and displays...
On optic nerve injury : experimental studies on axonal regeneration in the adult mammalian CNS
(2003-09-26)
Optic nerve injury may occur after a trauma to the head and in many cases it causes partial or total blindness. Today, these patients cannot be offered any specific treatment to restore visual function. The aim of this ...
Minimally invasive hernia surgery
(2003-04-25)
Minimally invasive laparoscopic and open tension-free techniques have been evolved during the 1990's. Different laparoscopic techniques have been used, where the totally extraperitoneal hernioplasty (TEP) is a technically ...
Reverse transcriptase assay for analysis of resistance to anti-HIV drugs and their mechanism of action
(2003-03-07)
. The CT assay and a modified IC assay that were supplemented with physiological concentration of GTP were applied for characterization of the RTs from 18 HIV-1 isolates with various susceptibilities to AZT in cell culture. Up to 9- fold and 600-fold...
Endocrine and metabolic aspects of adult Prader Willi syndrome with special emphasis on the effect of growth hormone treatment
(2003-09-05)
GH values, low total IGF-I and in relation to the obesity low levels of free IGF-I and non-suppressed IGF-binding- protein-1 (IGFBP-1). Approximately two thirds were biochemically hypogonadal. Bone mineral density (BMD) was low. Four patients had...
A concept for treatment of sports related knee injuries
(2004-04-02)
The aim of the present thesis was, to evaluate local anaesthesia as ananaesthetic technique when performing knee arthroscopies, from a clinicaland economical point of view, and to describe the total costs for surgeryof ...
Clinical and molecuar studies of papillary thyroid carcinoma : with an emphasis on prognostic factors
(2004-05-07)
Thyroid cancer accounts for approximately 1% of all cancers reported. In
Sweden 45/100, 000 inhabitants annually present with thyroid carcinoma.
There are four different variants of thyroid carcinoma: papillary ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
-I was reduced by 18%, while IGFBP-1 and IGFBP-4 were increased by 89 and 20 %, respectively. This complies with the lower BMD in the diabetic rats. In cortical bone, IGF-I was reduced by 38%, whereas no change was seen in ankles. The loss of IGF-I in cortical...
Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention
(2003-11-14)
cisplatin toxicity. However, i.v. administration of D-methionine 1 hour before cisplatin caused a 30% decrease in the systemic exposure to cisplatin and an even greater reduction in MHC exposure. Our results indicate that the previously observed protection...