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Horizontal gene transfer by uptake of apoptotic bodies
(2003-11-14)
In adults as well as during embryogenesis, apoptosis plays a key role in the elimination of cells in multicellular organisms. Apoptosis is important for the maintenance of tissue homeostasis. It is also of importance in ...
Human cytomegalovirus : development of resistance to antiviral drugs and mechanisms of NK-cell evasion
(2001-09-28)
Human cytomegalovirus (HCMV), a member of the herpesviridae, is
ubiquitous and causes persistent infections mostly without any clinical
symptoms. However, HCMV infection is a major cause of morbidity and
mortality among ...
Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide
(2003-03-07)
In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes ...
Occupational exposure to electromagnetic fields and chronic diseases
(2003-11-21)
This thesis consider two exposures from the electromagnetic spectrum extremely low-frequency magnetic fields (ELF MF) and ultraviolet (UV) radiation. ELF MF are the lowest and UV radiation ranges among the highest frequencies ...
Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3
(2003-05-02)
processed pseudogenes whithin a 1.4 Mb comprehensive transcriptional map. We identified and characterized four novel genes: FYVE and coiled-coil domain containing 1 (FYCO1), Transmembrane protein 7 (TMEM7), Leucine-rich repeat-containing 2 (LARRC2), Leucine...
Improving the situation of urinary bladder cancer survivors treated with radical surgery or radical radiotherapy
(2002-10-18)
in cystectomised patients with a urostomy, and a 7-fold increase of defecation urgency and faecal leakage was seen compared to matched controls (I). The risk of symptomatic urinary tract infections was increased 3-fold among the operated patients with a urostomy, i...
Targets for immune mediated killing of tumor cells and T cell functions in B-CLL
(2003-08-22)
There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of ...
New approaches for treatment of acute intermittent porphyria by enzyme substitution and gene therapy : evaluation in vitro and in vivo
(2004-05-07)
Acute intermittent porphyria (AIP) is a rare inborn metabolic error of
heme synthesis in which the activity of the third enzyme, porphobilinogen
deaminase (PBGD), is deficient. It is clinically characterized by ...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
induction therapy, in combination with ribavirin during treatment of naive patients, also resulted in a small but significantly more pronounced HCV RNA decline compared to standard dosing, in genotype non-1 infected patients but only day 2 and 7 during...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
IDDM is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting B- cells. GAD65 and IA-2 are major B-cell specific autoantibodies and are not found in healthy population. IDDM is associated ...