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CTLA-4 expression, regulation and associations in autoimmune myasthenia gravis
(2003-10-17)
Myasthenia gravis (MG) is a neuromuscular disease with muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR) on the skeletal muscle endplate. Cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) plays a...
Exploratory clinical development of ropivacaine, a local anaesthetic, in ulcerative colitis
(2003-04-18)
.
Fluvoxamine (a CYP1A2 inhibitor), but not ketoconazole (a CYP3A4 inhibitor), significantly affected the clearance of ropivacaine after single iv administration. This study confirms the in vitro findings indicating CYP1A2 as the most important enzyme...
Cervical cancer in Zimbabwe : viral and host factors : studies on pathogenesis of cervical cancer in Zimbabwe with special reference to type-specific human paillomavirus (HPV) infection and human cytokine gene polymorphisms
(2003-05-14)
, 18 and 31 were present in 61%, 39%, 18% and 4% of the cervical cancer samples respectively. HPV was identified and typed in 72% (31/43) of urine samples from cancer patients. There was an association between heterozygosity of the IL-10 (-1082 GA...
Population health and inequalities in health : measurement of health-related quality of life and changes in QALYs over time in Sweden
(2003-03-07)
). Corresponding differences in QALYs were 5.76 (4.14) in 1980 and 7.06 (5.66) in 1997, indicating an increase in inequalities in life expectancy and QALYs over time. However, the widening socio-economic inequalities were more stable for men than for women...
Development of new approaches for tumor suppressor genes identification
(2002-12-26)
Development of tumor is a complex process involving multiple steps. New technologies for cloning and identifying genes playing critical role in cancer development are necessary. That is why we have focused our research on ...
Autoimmune markers in autoimmune diabetes
(2003-12-19)
was negatively associated with younger onset (0-20 years) T1DM. MICA5/5.1 was associated with T1DM and LADA. Association of DR3-DQ2/DR4-DQ8 and DR3DQ2/DR3DQ2 with LADA as reported earlier was confirmed. We found DR3-MICA5.1 to be more significantly associated...
Natural and induced immunity against the tumour-associated antigen, Ep-CAM
(2003-11-27)
The tumour-associated antigen (TAA), Ep-CAM is overexpressed on various human carcinomas, including colorectal carcinoma (CRC). TAAs or their immunodominant epitopes that are spontaneously recognised by the immune system ...
New approaches for treatment of acute intermittent porphyria by enzyme substitution and gene therapy : evaluation in vitro and in vivo
(2004-05-07)
Acute intermittent porphyria (AIP) is a rare inborn metabolic error of
heme synthesis in which the activity of the third enzyme, porphobilinogen
deaminase (PBGD), is deficient. It is clinically characterized by ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Subcellular localization and signalling of Brutons tyrosine kinase (Btk)
(2002-11-28)
Brutons tyrosine kinase (Btk) is a non-receptor tyrosine kinase related
to the Src family of kinases. Mutations in various parts of the gene have
been shown to cause X-linked agammaglobulinemia (XLA), a primary
immunodeficiency ...