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A functional genomics approach to study prostate disorders
(2003-09-12)
Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized ...
Comparison of stereotactic fine needle aspiration biopsy and core needle biopsy in breast lesions
(2004-04-16)
the 1970th core needle biopsy (CNB) was developed and the method has later been refined. When we started our study 1993, CNB was not used in breast lesions in Sweden.
Biopsy technique: Spinal needles with diameter 0.7 and 0.9 mm were used for S...
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(2002-08-30)
This thesis investigates the influence of HIV on childhood tuberculosis
(TB) in a high TB and HIV endemic setting. It is based on four studies
involving the same study population of 522 tuberculous children and their
25 3 non-tuberculous controls...
Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism
(2003-05-02)
as a urinary collection was validated. Caffeine oral clearance (CL) in plasma correlated with that assessed in saliva (rs=0.97). The total oral caffeine CL correlated with the paraxanthine / caffeine concentration ratio in plasma (rs=0. 84), saliva (rs...
Endemic ataxic polyneuropathy in Nigeria
(2002-03-22)
in gari during storage were studied.
The prevalence of ataxic polyneuropathy was 490 per 10 000 in Ososa compared with 17 per 10 000 in Jobele. The age standardised prevalence ratio between Jobele and Ososa was 4 % (95 % Cl 0 - 9). The incidence...
Studies in nuclear receptor Nurr1 : identification of Nurr1-regulated genes
(2004-04-27)
The nuclear receptor family comprises more than sixty members, including
receptors for steroids, thyroid hormone and retinoids. Many nuclear
receptors function as ligand- activated transcription factors that
regulate ...
On the clinical value of genetic analysis in colorectal cancer patients
(2003-11-14)
In Sweden, the incidence of colorectal cancer (CRC) is about 5000 new cases every year and this number has not changed markedly during the past twenty years. 90-95% of all CRC appear spontaneously, but there are also ...
Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions
(2003-05-13)
Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept ...
Effects of anabolic hormone treatment in elderly patients with hip fracture
(2001-11-15)
The principal aims of these studies were to investigate the status of hip fracture patients regarding BMD, body composition and some nutritional factors at the time of the fracture and changes in these variables during the ...
Functional properties of antibodies in resistance against HIV-1 infection
(2002-02-22)
During the last years a few populations who remain uninfected despite repeated HIV-1 viral exposures have been described. Several mechanisms were suggested to be associated with this natural resistance including HIV-1-specific ...