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Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide
(2003-03-07)
potential beneficial effect of nicotinamide in endotoxemia. We demonstrate that nicotinamide is a potent inhibitor of three major endotoxin induced proinflammatory cytokines, Il-1 beta, IL-6 and IL-8, in addition to the previously known TNFalpha inhibiting...
Health risk assessment of dioxin-like compounds in complex samples
(2003-10-10)
screening tools for dioxin-like compounds to complement the chemical analysis. In this thesis, the MH1C1-EROD-assay was shown to readily assess dioxin-like potency in various complex samples (Study IV). In addition, the use of a clean-up procedure...
HMBG1 as a proinflammatory mediator in arthritis
(2003-05-02)
Proinflammatory cytokines are central in the pathogenesis of chronic arthritis and a new generation of therapeutics blocking TNF or IL-1 has improved outcome for many patients with inflammatory joint diseases. This thesis addresses the role of HMGB1...
The normal and ACL deficient knee : an in vivo three dimensional kinematic and electromyographic analysis
(2002-12-27)
3.7 mm (range 1.2 to 7.3 mm) and 6.1 nun (range 1.4 to 10.3 nun) for the jump and cut respectively. The level of activity may not have been adequate to provoke the large displacements in order to identify whether knee braces reduced pathological...
The use of mass spectrometry and DNA technology in the investigation of hemoglobin disorders
(2003-03-07)
Hemoglobin (Hb) disorders, which severely affect nearly 300,000 newborns every year, have become a global problem. The disorders manifest a wide spectrum of clinical symptoms ranging from asymptomatic to lethal conditions. ...
Long term health-related quality of life among women with high-risk breast cancer receiving adjuvant high-dose chemotherapy : a comparison with the normal population
(2002-02-01)
The aims of the thesis were 1) to provide reference values for the EORTC QLQ-C30 in the general Swedish population, 2) to investigate effects of adjuvant high-dose treatment on health-related quality of life (HRQoL) among high-risk breast cancer...
Haemodynamic and ventilatory effects of laparoscopic surgery
(2004-01-23)
Background: It has been shown repeatedly that the establishment of pneumoperitoneum (PP) is associated with increased cardiac filling pressures, as well as increased blood pressure and systemic vascular resistance. Patients ...
A study of neuropeptide Y in brains of 'depressed' and healthy rats
(2001-10-12)
RNA expression was lower in
hippocampal CA and dentate gyrus of the FSL rats. We also found that Y1
binding sites are increased in the CA region of these animals. These
results support our hypothesis that an NPY hypofunction, possibly
secondary to decreased NPY...
Clinical molecular imaging of schizophrenia
(2003-08-22)
The aim of this thesis was to examine pathophysiology and antipsychotic treatment of schizophrenia by using positron emission tomography (PET).
The high affinity radioligand [11C]FLB 457 was used for determination ...
Clinical and genetic investigation of hypochondroplasia and dyschondrosteosis
(2001-09-07)
Linear body growth is a multifactorial trait influenced by many environmental and intrinsic factors. Among the intrinsic determinants of body height, genetic and endocrine factors are considered to be the most important. ...