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Signalling and activation of TLR4 by Gram-negative bacteria in epithelial cells
(2003-05-16)
Lipopolysaccharide (LPS) is a well-characterized pathogen-associated molecule found primarily as a constituent of the outer membrane of Gram-negative bacteria. LPS is known to act on different cell types in a pleiotropic ...
Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human
(2004-01-29)
Cyclophosphamide (CPA) is widely used anti-cancer drug that has to be
catalyzed by the cytochrome P450 (CYP) enzyme 2B6 as well as some other
CYPs to exert its cytotoxic activity. A high degree of interindividual
variation in CPA kinetics has been...
Molecular epidemiology of hepatitis A and hepatitis B virus in central America
(2002-04-17)
of the predicted amino acid substitutions of the obtained sequences with the substitutions known conserved for each genotype. Genotype F was found in 79% of the strains and genotypes A, D and C were represented by 14%, 6% and 1 % of the strains, respectively...
Proinsulin C-peptide : membrane interactions and intracellular signaling
(2004-05-13)
In the past decade, new evidence has emerged of a physiological role for
C-peptide. C-peptide replacement improves renal and nerve function and
augments regional blood flow in type I diabetic patients. Data
demonstrate ...
Allogeneic stem cell transplantation in children : identification and prevention of complications : adoptive transfer of EBV-immunity
(2003-01-24)
centre, median time to relapse was 24 months in patients with chronic GVHD and 6 months in those without. The 5-year probabilities of relapse were 30 and 45% (p=0.01). Patients with chronic GVHD had a better survival, 77 vs. 51% (p=0.01). In a Cox...
Upholding older adults innate and inherent dignity within a caring context
(2002-10-10)
or not this was a practicable strategy to influence individual health care members attitudes as well as their ethical caring behaviour with a special focus on the patients autonomy and integrity. A 6 and 12 months follow up was performed including group...
HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden
(2001-08-08)
Infection with human papillomaviruses (HPV) types 16 and 18 is the major
cause of cervical neoplasia. Although a high proportion of cervical
cancers (CXCA) harbor HPV genomes, only a small number of women infected
with ...
Elucidation of pro-apoptotic signaling induced by cisplatin
(2003-02-07)
A major clinical problem regarding treatment of malignant tumors with anticancer drugs is inherent or acquired resistance to therapy. One factor contributing to drug resistance of cancer cells is failure to undergo apoptosis. ...
Studies on autoimmune diabetes in Latvians and other populations
(2001-10-09)
IDDM is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting B- cells. GAD65 and IA-2 are major B-cell specific autoantibodies and are not found in healthy population. IDDM is associated ...
Radiologic diagnosis of appendicitis in children
(2004-04-23)
Suspected appendicitis is the most common cause of emergency abdominal surgery in children. Because of the often atypical clinical findings, the diagnosis of appendicitis is difficult and may be delayed. Perforation has ...