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Voltage sensor movements in shaker and HCN channels
(2003-11-14)
Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, and an ion...
Tracer development and PET studies : labeled proinsulin C-peptide and an EGFR-TK inhibitor
(2002-05-17)
Positron emission tomography (PET), which localizes and quantifies
positron decays over time, enables non-invasive in vivo distribution
studies of trace amounts of compounds labeled with positron emitters. The
use of ...
Structure and function of hepatic cytochromes P450 : implications for drug development
(2002-11-25)
6 allele (CYP2D6*17) common in Black African populations
carrying three mutations Thrl07IIe, Arg296Cys and Ser486Thr was
investigated by recombinant expression and the enzyme characterized using
CYP2D6 specific substrates. It was found that both...
Regulation of B cell motility and adhesion in health and disease
(2003-11-07)
Migration and adhesion of lymphocytes are crucial to induce an efficient immune response. These activities rely on cytoskeletal dynamics, mediated by assembly of actin and microtubuli monomers leading to changes in cell ...
Epidemiology and pathogenesis of HHV-6
(2002-01-04)
Human herpesvirus-6 (HHV-6), a beta-herpesvirus, was discovered in 1986. It is divided into two variants, A and B. HHV-6 variant B is the cause of exanthema subitum, while variant A has not yet been associated to any disease. HHV-6 is ubiquitous...
Immunogenetic markers in immune mediated diseases
(2003-11-21)
connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM).
HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune-mediated diseases due to the function of the molecules...
Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease
(2002-05-20)
We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP).
In a series...
Dentin surface conditioning : the role of collagen in dentin bonding
(2001-12-28)
Preparation of dental cavities inevitably produces a thin layer of smear, which covers dentin and enamel surfaces. This smear layer, which is between 1 and 10 gm thick, consists of hydroxyapatite, denatured collagen and ...
In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia
(2002-11-08)
Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity ...
Quinolone resistance in Bacteroides fragilis and Pseudomonas aeruginosa, two opportunistic pathogens
(2003-04-08)
Opportunistic pathogens can cause infections in case of structural or functional defects in the host. Examples of Gram-negative opportunists are the Bacteroides fragilis group, anaerobic, non-spore forming rods and the ...