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Galanin and Leu-enkephalin in the rat : with special reference to adjuvant arthritis
(2004-05-20)
In these studies, the tissue and cellular distribution of Galanin and
Leu-enkephalin were demonstrated in normal bone and joints. Furthermore,
tissue levels of Galanin and Leuenkephalin were also studied in the
ankles ...
Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism
(2002-11-15)
CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of ...
Experimental nerve injury : induced pain : mechanisms and modulation
(2004-03-26)
Chronic nerve injury-induced pain presents a therapeutic challenge since
such pain is often resistant to conventional analgesic drugs including
opioids. Better knowledge of the pathophysiological mechanisms underlying
nerve ...
Genetic and environmental influences on major recurrent headaches
(2004-01-09)
.0001) and these proportions increased with increasing
age. A significant variation in heritability of migraine headache across
age groups ranging from 91% (15-20 years) to 37% (41-47 years) was
detected in women (chi2 =20.29, P<0.025). This variation was explained by
less...
Novel aspects of Na+,K+-ATPase
(2002-09-13)
activated the transcription factor NF-kappaB. The oscillations required Ca 2+ influx from extracellular space and release from intracellular stores. The IP3R, located in the ER membrane, was found to play a pivotal role in initiation and maintenance of Ca 2...
Shock wave effects on the vascular endothelium
(2002-05-24)
A shock wave is a pressure wave with high amplitude and a velocity above sound. Man is exposed to shock waves (SWs) in connection with trauma, e.g. explosions and high-energy missiles and medical treatments such as ...
Molecular and diagnostic aspects of the protein p41 of HHV-6 and silencing of the CD46 receptor by RNA interference
(2003-05-23)
Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS), leading to sensory and motor disability in young adults. There is no efficient treatment of the disease. Its etiology is ...
Affective disorders in a stress-vulnerability perspective : a clinical, biological and psycho-social study
(2002-11-15)
major aetiological role in affective illness and influence the age of onset in bipolar illness; (2) life events are of greater importance early in the course of affective illness; and (3) bipolar patients with cognitive impairment, a low level...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
quinazolines, a type of heterocyclic compounds that is considered to be highly interesting as scaffolds for development of new drugs. When the acyl halide was a tertiary 2-haloacyl halide, the reaction instead gave 1,4-benzodiazepine-3-ones via rearrangement...
Life without thyroid hormone receptors
(2003-08-08)
. This hormone-mediated gene regulation is a finely tuned interplay of numerous parameters. These include i) usage of several isoforms of receptors (TRa1, TRb1, TRb2, TRb3) encoded for by two distinct genes, ii) receptor-mediated repression of target gene...