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Molecular mechanisms in amyloid fibril formation
(2004-05-21)
This thesis concerns investigations on molecular processes and interactions that lead to amyloid fibril formation. Pulmonary surfactant protein C (SP-C), and a synthetic analogue thereof, SP-C(Leu), have similar properties ...
Time dependency in the protection from myocardial injury after myocardial ischemia and reperfusion : new insights from experimental studies with the ultrashort-acting calcium antagonist clevidipine
(2002-05-24)
the ischemic tissue.
In Study III pigs were subjected to 45 min of myocardial ischemia
followed by 120 min of reperfusion via the left internal thoracic artery
using an off-pump coronary arterial bypass grafting model. The animals
were divided into 4 groups...
Facilitation of recovery after ischaemic stroke : early dexamphetamine and physiotherapy treatment
(2003-11-28)
Purpose: The overall aims of the thesis were to investigate the safety, efficacy, and pharmacokinetics of dexamphetamine (d-amph) after cerebral infarct, and the effects of different amounts of physiotherapy in combination ...
Monitoring of antiepileptic drugs using microdialysis : methodological and clinical aspects
(2002-10-25)
In therapeutic monitoring of antiepileptic drugs (AEDs) the level of unbound drug at the sampling site should ideally equal the unbound concentration at receptor sites. Microdialysis enables direct sampling of the unbound ...
Studies of cell migration and matrix protease production in human lung cancer cell lines
(2004-09-03)
Metastatic spread in cancer is a complex multistep process involving
continuous, sequential interactions between tumour cells and their
respective microenvironment. Invasiveness per se has not been studied in
this thesis, ...
Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases
(2003-05-15)
for the role of RDH5 in 11-cis retinal synthesis was provided from mutations found in the RDH5 gene that caused fundus albipunctatus, a stationary form of night blindness. Intriguing was that both RDH4 and RDH5 enzyme domains faced the endoplasmic reticulum (ER...
Hepatitis C virus kinetics during antiviral treatment
(2004-03-05)
It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear ...
Birth centre care : reproduction and infant health
(2004-04-02)
This thesis has two general aims, to investigate factors affecting
women s decision to have a second baby and to study the effect of birth
centre care on infant outcome. The specific aims were to investigate 1)
whether ...
Studies on human polyomavirus infection in immunosuppressed patients with polyoma related tumors
(2001-09-21)
Polyomaviruses are potentially oncogenic viruses, found in humans, in other mammals and in birds all over the world. The polyomaviruses that have been observed in humans are BK virus (BKV) and JC virus (JCV) as well as the ...
Diagnostic evaluation of fetal death with special reference to intrauterine infections
(2002-05-10)
The incidence of intrauterine fetal death (>=28 gestational weeks) is approximately 4/1000 births in Sweden. In order to arrive at a potential cause of death, a number of investigations have been recommended in the diagnostic evaluation...