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STAT5 expression and regulation in mammary epithelial cells
(2004-01-09)
) can activate latent cytoplasmic transcription factors of the signal transducer and activator of transcription (STAT) family of proteins. In particular the two STAT5 isoforms, STAT5A and STAT5B, are associated with effects of PRL. In this thesis...
Management of Helicobacter pylori infection in Vietnam
(2004-05-07)
simple and efficacious treatment regimen and to evaluate the accuracy of the non-invasive ELISA method for use in Vietnam.
Methods: In a randomised clinical study in Vietnam, 296 patients with peptic ulcer disease and H. pylori infection were included...
Structure and function of hepatic cytochromes P450 : implications for drug development
(2002-11-25)
6 allele (CYP2D6*17) common in Black African populations
carrying three mutations Thrl07IIe, Arg296Cys and Ser486Thr was
investigated by recombinant expression and the enzyme characterized using
CYP2D6 specific substrates. It was found that both...
On the clinical value of genetic analysis in colorectal cancer patients
(2003-11-14)
In Sweden, the incidence of colorectal cancer (CRC) is about 5000 new cases every year and this number has not changed markedly during the past twenty years. 90-95% of all CRC appear spontaneously, but there are also inherited forms of CRC (5...
Pulmonary tuberculosis and HIV interaction in a setting with a high prevalence of HIV : clinical, diagnostic and epidemiological aspects
(2002-05-17)
(OR 2.10; 95% CI 0.85-5.25). In total, 17 bit of 121 isolates (14.0%) were, resistant to one or more of the standard anti-tuberculous drugs. Inpatients 35-44 years old the high rate of drug resistant isolates (29.6%) coincided with the peak HIV...
Genetic studies of susceptibility to diabetes mellitus with emphasis on type 1 diabetes
(2003-05-02)
2p (p = 9 x 10-4), 5p11-q13 (p = 8 x 10-4), and 16p (p = 2 x 10-4). The region on chromosome 2p includes the EIF2AK3 gene, which has been implicated in a rare form of very early onset insulin-dependent diabetes. However, association to T1DM...
p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation
(2003-01-10)
proliferation. Further investigation also identified a functional glucocorticoid response element (GRE) in the human p5 7Kip2 promoter, located 5 kb upstream of the transcriptional start site. The GRE was also shown to be well conserved in the mouse both...
Clinical pharmacokinetics of intravenous ethanol : relationship between the ethanol space and total body water
(2001-10-26)
Introduction: Total body water (TBW) is an important parameter in
pathological states where the normal regulation of fluid balance is
impaired (e.g., during critical illness, congestive heart failure, bum
injury and ...
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(2002-08-30)
, consecutively enrolled as out- and
inpatients at the major paediatric hospital in Addis Ababa, Ethiopia.
The first study identifies HIV as a major risk factor for TB. HIV
prevalence among tuberculous children in Addis Ababa was 12.5%, compared
with 1.6% among...
HIV-induced humoral immune response with specific relevance to IgA
(2002-05-17)
with broad co-receptor usage of the virus. To further elucidate the mechanisms of SLPI in the entry stage of the lifecycle of HIV1, we used a panel of virus isolates with distinct molecular phenotype. The monotropic strains, using either CXCR4 or CCR5 were...