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Plasticity of the dopamine1 receptor and its signaling pathway
(2003-09-12)
Dopamine 1 receptor (D1R) belongs to the G protein coupled receptor superfamily with seven transmembrane domains. Previous studies from our laboratory showed that D1R availability in the plasma membrane of renal epithelial ...
Pharmacokinetic studies on cladribine
(2001-11-23)
is in this study not superior to administer all patients a fixed dose.
The metabolite CAde has a lower cytotoxic effect than CdA, but may contribute to the cytotoxicity after oral administration, since 5 times more CAde was formed after oral treatment than after...
Combined radiology and cytology in the diagnosis of bone lesions : a study of 494 patients
(2002-11-22)
diagnosis was given by the cytologists in 22 and 23 cases, respectively, incorrect in 2 and non-conclusive in 5 and 4. The study suggests that true tumour heterogeneity is rare. The interobserver difference and diagnostic difficulties should mainly...
Studies of polyglutamine repeats and their biology in relation to disease
(2001-08-23)
and to
identify interacting factors. It was possible to obtain up to a 5.5 fold
increase in the yield of the reaction after optimization of the protocol.
In parallel with the optimization procedure, candidate diseases were
analyzed by the RED method...
Molecular consequences of cellular UDP-glucose deficiency
(2004-05-21)
. This was associated with almost complete inactivation of the enzyme (= 5% of G3 activity). The amount of GS protein in Qc cells was 50% of the amount in G3 cells and this decrease was associated with lower GS mRNA levels in the UDPG deficient cells.
Comparable...
Trinucleotide repeats and neuropsychiatric phenotypes
(2001-11-02)
. The frequency of individuals with expanded SCA8 repeats (>40 repeats) was higher in all the four patient groups as compared to healthy individuals. Expanded alleles within the SCA8 pathogenic size range (107-127 CTG repeats) were detected in 5 affected...
Population-based studies of body mass index, overweight and systolic blood pressure among Swedish young men
(2002-08-30)
Overweight and obesity has increased in Sweden and worldwide in recent decades. Lifestyle and environmental changes, genetic susceptibility and interactions between these factors are believed to be important. A theoretical ...
Cellular markers indicating activation of the hemostatic system : studies on platelets and leukocytes in peripheral human blood
(2003-11-28)
individuals. The fibrinogen binding was reversible after a maximum at 5 minutes after stimulation, possibly due to an internalisation of the receptor a few minutes after stimulation. Von Willebrand factor on the other hand increased, and remained at its...
Centrosome aberrations and tumor development
(2003-08-15)
The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and ...
Medical interventions and gastric cancer risk : an observational approach
(2004-05-14)
treatment (OR, 0.7 95% Cl, 0.5- 1. 1) conferred a
reduction in gastric cancer risk.
To further test the hypothesis that exposure to heavy antibiotic
treatment reduces the risk of gastric cancer, we assessed cancer risk
among 336,017 patients hospitalized...