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Student-environment fit for students with physical disabilities
(2002-08-09)
The overall aim of the research presented here was to identify and
explore aspects of the school environment that influence the
participation of students with physical disabilities. The first study
examined the reliability ...
Bioinformatic methods in protein characterization
(2002-11-08)
Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among ...
Use of primary human hepatocytes for the elucidation of bile acid synthesis
(2003-01-03)
In the present investigation we cultured primary human hepatocytes on matrigel under serum-free conditions and studied bile acid formation. The following observations were made:
· The major steroid products excreted ...
Glucocorticoids in the development and homeostasis of T lymphocytes
(2002-05-24)
Until recently the fact that glucocorticoids (GCs) play an essential physiological role in regulation of the immune system in health and disease was not fully appreciated. The main aims of this thesis were to investigate ...
Outcome after surgery of congenital cataract
(2002-05-03)
The visual outcome in infants undergoing surgery for bilateral congenital cataract has improved considerably because of improved surgical methods and the realisation that early detection, allowing early cataract extraction ...
The life and death of the notch intracellular domain
(2003-02-28)
The Notch signaling pathway is an evolutionarily conserved way of communicating between cells that contact each other. Notch is a single-transmembrane spanning receptor that interacts with single-transmembrane spanning ...
Genetic differences in neuropathy and opioid responses in rats
(2003-11-28)
The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic ...
Virulence mechanisms of two gram negative bacteria : studies on Escherichia coli hemolysin HlyA and on the interaction of Brucella abortus with non-phagocytic cells
(2002-01-25)
Virulence factors may be classified in two general groups: those that
cause damage to the host and those that promote bacterial colonization
and invasion. In this study, the tissue damaging Escherichia coli
hemolysin ...
SNP based strategies to study candidate genes for Alzheimer’s disease
(2002-11-08)
haplotypes were always over-represented in cases compared to controls, or with more severe AD within the patient groups. These results indicate a role in AD for one of the three genes situated within the 276kb LD block including the IDE, KNSLI and HHEX genes...
Modulation of bile acid and cholesterol metabolism in health and disease
(2004-05-07)
of C4 in 276 healthy individuals was skewed. The level of C4 did not change with age, whereas females had 15% lower serum C4 as compared to males. There was a correlation between serum C4 and total triglycerides. Statin treatment did not alter plasma C4...