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Immunopathogenic mechanisms in inflammatory myopathies
(2002-11-14)
different proportions of CD4+ and CD8+ T cells and macrophages with various localizations in the different subsets of IIMs. However, it is unknown what mechanisms underly the clinical symptoms of muscle weakness. One would assume that the presence...
Hypoxia inducible factor 1alpha : molecular mechanisms of regulation
(2002-05-24)
Hypoxia-Inducible Factor 1alpha (HIF-1alpha) is an important protein in the homeostatic control of genes in response to low oxygen, or hypoxia. It is thus also a key factor in the regulation of angiogenesis in response to ...
Regulation of dioxin receptor function by the Hsp90 chaperone complex
(2002-03-22)
In mammals the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors includes the dioxin receptor which is a ligand-dependent transcription factor which mediates biological effects of environmental ...
Functional studies on the nuclear receptor Nurr1
(2004-04-28)
The nuclear receptor (NR) superfamily comprises the largest family of ligand-activated transcription factors in eukaryotes, and it plays critical roles in many aspects of vertebrate development and physiology. The NR family ...
Mechanisms of activation of the hypoxia-inducible transcription factor 1a
(2002-04-05)
Hypoxia Inducible Factor-1 is a heterodimeric transcription factor composed of the bHLH/PAS factors HIF-1 alpha and HIF 1 beta/ARNT. Under hypoxic conditions HIF-1 becomes activated and transcriptionally upregulates a set ...
Socio-economic consequences of longstanding illness
(2002-08-09)
This thesis focuses an old research area of social medicine, the social and economic consequences of chronic illness and factors modifying this effect. Historically, illness was the main predictor of poverty. Since then, ...
Crystallographic studies of enzymes involved in biosynthesis of fatty acids : beta-ketoacyl-acyl carrier protein synthase II and delta9-stearoyl-ACP desaturase
(2003-05-16)
In the biosynthesis of fatty acids, the beta-Ketoacyl Acyl Carrier Protein Synthases (Kas) catalyse chain elongation by the addition of two-carbon units derived from malonyl-ACP, to an acyl group bound to CoA or the small ...
Molecular epidemiology of human papillomavirus and cervical cancer
(2001-11-16)
from Stockholm (Sweden), where 218 cervical cancer
cases and 219 healthy controls were enrolled and followed up regarding
survival; A cross-sectional survey of healthy Swedish women, where a randomly
chosen subsample of 274 women was evaluated; A...
Aspects of gastroesophageal reflux and risk for esophageal cancer : an epidemiological approach
(2003-10-24)
into the effects of anti-reflux surgery, and to shed light on some possible mechanisms behind the alleged carcinogenicity.
Methods: We estimated relative risk for esophageal adenocarcinoma in a cohort of 35,274 male patients hospitalized for gastroesophageal...
Studies on the atypical orphan receptor SHP
(2001-11-23)
Nuclear receptors (NRs) comprise the largest family of transcription factors in eukaryotes and play critical roles in nearly every aspect of vertebrate development and adult physiology. In general, they function as ...