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The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae
(2003-08-08)
Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media and respiratory tract infections. Its lipopolysaccharide (LPS) molecule, an outer membrane component, is a major virulence factor of NTHi. The ...
Bioinformatic methods in protein characterization
(2002-11-08)
Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among ...
Structural studies of some bacterial polysaccharides and extension of a method for lipid A cleavage
(2002-09-13)
The focus of the work presented in this thesis has been to study the
structures of the capsular polysaccharide from Serratia marcescens
O14:K12, and the O-antigen polysaccharides from Hafnia alvei strain 10457
and Vibrio ...
Studies on immunological mechanisms of induced arthritis in the rat
(2002-11-22)
erosions of bone and cartilage. The
influence of MHC as well as non-MHC genes has been demonstrated in both
these models.
In the first paper we evaluated the contribution of CD4+ and CD8+ T cells
respectively, to development of disease. This was performed...
Affective disorders in a stress-vulnerability perspective : a clinical, biological and psycho-social study
(2002-11-15)
positive family history of affective illness, compared to those without a family history. Furthermore, bipolar patients with heredity, had less life events at onset. Bipolar patients with preceding life events had a 4.8-year higher onset, compared to those...
Proteins influencing the integrity of meiotic chromosome dynamics
(2002-08-09)
Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called ...
Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients
(2003-09-05)
The age-adjusted incidence rate of non-Hodgkin´s lymphoma (NHL), in particular diffuse large B cell lymphoma, has increased continuously during several decades. Patients with aggressive NHL are potentially curable but the ...
Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas
(2002-10-03)
Characterization of human tumors with associated genetic changes is of importance for better understanding the tumor's basic biological behavior and of great value for clinical management of cancer patients. We therefore ...
Determinants of ligand-induced nuclear receptor activation
(2004-05-13)
The nuclear receptors (NRs) constitute a highly conserved superfamily of transcription factors restricted to metazoans. In general, these receptors are regulated by small lipophilic molecules such as steroids, thyroid ...
Diabetic skin microangiopathy : studies on pathogenesis and treatment
(2003-10-31)
Background: Most of late diabetic complications have their basis in a disturbed microcirculation, i.e. diabetic microangiopathy. This along with peripheral arterial occlusive disease (PAOD) and neuropathy contribute to the ...