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Tobacco smoking, vascular reaction and neutrophil activity in periodontal health and disease
(2003-01-03)
III and IV, the influence of tobacco smoking on the presence, in GCF, of neutrophil derived elastase and LF and the protease inhibitors alpha-1-AT and alpha-2- MG was studied. It was found that under clinically healthy periodontal conditions...
Risky alcohol consumption in the workplace : the feasibility of early detection and brief intervention as a part of routine health examinations
(2002-03-27)
not drink more alcohol than permanent day workers, according to the AUDIT, CDT and GGT results. In fact, the opposite was observed for 2-shift workers according to CDT. Of those employees who participated in the follow-up, almost 50% had negative test...
Mass spectrometry in the search for new drugs of abuse : method development and clinical application
(2004-02-27)
clinic. Novel findings included zopiclone, zolpidem, zaleplone,
N-benzylpiperazine and 1-phenyl-2-butylamine. MDMA was the most common
finding followed by zopiclone. In samples from methadone patients only
the hypnotics could be detected. Similarly...
Experimental nerve injury : induced pain : mechanisms and modulation
(2004-03-26)
Chronic nerve injury-induced pain presents a therapeutic challenge since
such pain is often resistant to conventional analgesic drugs including
opioids. Better knowledge of the pathophysiological mechanisms underlying
nerve ...
Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers
(2001-12-21)
The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus...
Genetic and environmental influences on major recurrent headaches
(2004-01-09)
.0001) and these proportions increased with increasing
age. A significant variation in heritability of migraine headache across
age groups ranging from 91% (15-20 years) to 37% (41-47 years) was
detected in women (chi2 =20.29, P<0.025). This variation was explained by
less...
Genetic background of familial primary hyperparathyroidism
(2003-04-11)
of other familial forms of PHPT e.g. MEN 1 and HPT-JT. In an attempt to clarify the underlying cause of FIHP, the MEN1 gene and the HRPT2 gene locus were investigated by mutation screening, loss of heterozygosity (LOH) and comparative genomic hybridisation...
Cloning and characterization of human glutaredoxins
(2002-05-24)
disulfides.
A novel human glutaredoxin, Grx2, localized at chromosome 1 was identified and cloned. Recombinant human Grx2 exhibited GSH-dependent hydroxyethyl disulfide reductase activity (BED-assay), typical for glutaredoxins. Secondary structure...
Multiple sclerosis linkage analysis and DNA variation in a complex trait
(2004-01-23)
displaying a possible monogenic inheritance pattern. The result from the screen gave one peak on the long arm of chromosome 9 between markers D9S175 and D9S261. The highest LOD score revealed a suggestive LOD score of 2.29 (P value 0.0009) close to marker D9...
Mechanisms of activation of the aryl hydrocarbon receptor by novel inducers of the CYP1A1 gene
(2003-05-23)
for the AhR is the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The present study was undertaken in an attempt to elucidate the mechanism of activation of the CYP1A1 gene by several compounds that recently have been reported...