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Thioredoxin reductase and selenium in carcinogenesis and multidrug resistance
(2004-05-21)
The thioredoxin system, comprising thioredoxin, thioredoxin reductase (TrxR) and NADPH, is a redox system of great importance in the defence against oxidative stress and is involved in the regulation of several cellular ...
Cognitive functioning in aging and dementia : the role of psychiatric and somatic factors
(2002-05-24)
This doctorial thesis concerns the role of psychiatric and somatic factors in aging and dementia. Five studies are included, all based on data from the Kungsholmen Project, a population-based longitudinal study of aging ...
Early detection of colorectal cancer
(2004-03-05)
-99. The median work-up-time was 42 (QR 12-110) days for colon cancer and 23 (QR 0-49) days for rectal cancer. A family history was documented on the first visit in 2 /179 (1%) cases. For patients with right-sided cancer and a positive F-Hb, the median work...
Ventricular repolarization in the human heart : effects of pharmacological and non-pharmacological interventions
(2001-11-02)
of the
acquired Long QT Syndrome.
Based on a retrospective analysis of 259 patients, we suggest as a
routine pacing at a rate of 80 bpm during the first week after ablation
to decrease the risk for serious arrhythmic events, and monitoring in
hospital...
Neuropeptide expression in mouse disease models
(2003-05-07)
The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of ...
Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes
(2003-10-24)
The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to drug metabolism, in particular CYP3A4. responsible for the metabolism of a majority of drugs being metabolized in order ...
Proteins influencing the integrity of meiotic chromosome dynamics
(2002-08-09)
Aneuploidy (trisomy or monosomy) is the leading genetic cause of human pregnancy loss and results from aberrant meiotic chromosome segregation. Accurate segregation of meiotic chromosomes depends on extensive pairing (called ...
Muscarinic M1 and M4 receptor subtypes in normal and pathological conditions in the central nervous system : studies on human and animal tissues using subtype selective ligands
(2003-08-20)
Snake venoms from different mamba species contain toxins that bind to muscarinic acetylcholine receptors (mAChR). The toxins MT-1 (selective for M1 after iodination), M1 toxin-1 (also known as MT7, selective for MI) and ...
Vestibular control of body orientation in lamprey
(2004-03-26)
Maintenance of body orientation (postural control) is a vital motor function of the brain. The general goal of this project was to understand the organization and operation of neuronal networks responsible for postural ...
Minimally invasive hernia surgery
(2003-04-25)
/inflammations, including intestinal obstruction, 58.99. The RR was 2.79 with TAPP and 0.57 with TEP compared to Lichtenstein operated patients....