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Protein modification with hydrophobic prenyl groups in malignant cells
(2001-10-19)
Mevalonate (MVA) is the key intermediate in the isoprene synthetic
pathway leading to the formation of a number of biologically important
lipid molecules. It is well known that inhibition of MVA synthesis blocks
the cell ...
Mechanisms of regulation of dioxin receptor function
(2002-05-23)
The dioxin receptor is a ligand-inducible transcription factor that belongs to the basic helix-loop- helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors. The dioxin receptor is regulated in a spatial manner, where ...
Sialic acid : a new potential marker of alcohol abuse
(2002-08-16)
Biological markers have been used for several years to detect heavy alcohol consumption or organ damage induced by alcohol. Early identification of alcohol abuse or alcohol dependence could increase the likelihood of early ...
Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1
(2004-01-30)
Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by
altering neuronal signal transduction pathways, by increasing AP
production or by triggering a number of proapoptotic mechanisms. The
present ...
Assessment of physical activity and energy expenditure in adolescents
(2002-04-15)
defining PA intensity levels; 3) in a random sample of 14-to-15-year-old adolescents, approximately 30% of the boys and girls did not achieve appropriate levels of PA according to published recommendations; and 4) the relationship between TEE and its...
Maternal deaths in Mozambique : an audit approach with special reference to adolescence, abortion and violence
(2002-05-15)
in non-adolescents, and the prevalence of risk factors used in antenatal cards with the intention to identify "high risk pregnancy" among such women, 4: to review pregnancy-related deaths due to injuries in HCM, and to elucidate the contribution...
Health economic assessment of medical technology in chronic progressive diseases : multiple sclerosis and rheumatoid arthritis
(2003-09-26)
disease progression compared to the natural history data. As a consequence, the cost per QALY gained with 3-year treatment over a 10-year timeframe dropped from 342'700 SEK in the first study to 257'200 SEK in the second. When the model is applied...
Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation
(2002-04-05)
regulation of ER values.
FNA biopsies were used to assess epithelial proliferation in normal breast tissue from 106 healthy premenopausal women with and without oral contraceptives. OC users had a higher (p=0.03) proliferation rate (mean 4.8 % of KI-67/MIB...
Candidate gene analyses and genome-wide screens in multiple sclerosis
(2002-11-29)
Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. ...
HIV-induced humoral immune response with specific relevance to IgA
(2002-05-17)
potential epitopes for salivary and serum derived lgA antibodies. lgA mediated response against HIV-1 was found to be mainly directed against epitopes in the second and fourth variable regions (V2 and V4) of gpl20. In contrast, we found strongest lgA binding...