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Structural studies of bacterial carbohydrate antigens with focus on oral commensal bacteria
(2002-08-15)
90% of the total number of cells in the human body consist of the normal
bacterial flora. These bacteria are mostly not harmful and, indeed, even
beneficial as long as they remain physiologically outside the body, e.g.,
within ...
Cognitive functioning in aging and dementia : the role of psychiatric and somatic factors
(2002-05-24)
This doctorial thesis concerns the role of psychiatric and somatic factors in aging and dementia. Five studies are included, all based on data from the Kungsholmen Project, a population-based longitudinal study of aging ...
A reason to be bitter : cassava classification from the farmers' perspective
(2001-11-16)
exposure was negligible inspite of frequent consumption of food
made from soaked roots from "bitter" cassava cultivars.
In 1996 two roots from 246 plants of the 10 most grown cultivars, about
24 plants from each cultivar were harvested. Farmers' scoring...
Case-crossover studies of the triggering of disease : myocardial infarction and Ménières disease
(2003-05-07)
-referent study including all cases of first-time MI (n=2,246) occurring in Stockholm County from 1992 to 1994; the Onset study, a case-crossover study of all eligible nonfatal cases (n=699) in SHEEP 1993 to 1994; and, the study of triggers of attacks of Ménières...
Germline CDKN2A/ARF alterations in human melanoma
(2002-03-01)
is complex and heterogeneous. To date only two melanoma predisposing genes have been identified. The CDKN2A/ARF locus on human chromosome 9p21 encodes two distinct cell cycle regulatory proteins, p16 and p14ARF. Germline alterations in the CDKN2A gene have...
Molecular mechanisms involved in the growth of human uterine leiomyomas
(2002-11-14)
Human uterine leiomyomas (fibroids) are benign neoplasms arising from uterine smooth muscle cells, and are suggested to be sex steroid dependent. The aim of this study was to investigate the molecular mechanisms by which ...
The role of human papillomavirus in adenocarcinoma of the uterine cervix
(2002-05-03)
Background: Cervical carcinoma is the third most common malignant disease
in women worldwide. The absolute frequency of adenocarcinoma of cervix
uteri has increased during the last decade and accounts for about 15-20%
of ...
Spinal cord injury : mechanical and molecular aspects
(2002-05-10)
Traumatic spinal cord injury leads to full or partial paralysis and loss
of sensation below the level of injury. The annual incidence of spinal
cord injury in the United States is 3-5 per 100,000 and in Sweden is
1.5-2 ...
Growth factor pathways in human cancer : functional and therapeutic implications
(2002-10-04)
The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric ...
Apolipoprotein E and Alzheimer's diseases : signals and effects
(2002-04-26)
Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. ...