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Outcome after surgery of congenital cataract
(2002-05-03)
The visual outcome in infants undergoing surgery for bilateral congenital cataract has improved considerably because of improved surgical methods and the realisation that early detection, allowing early cataract extraction ...
Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human
(2004-01-29)
Cyclophosphamide (CPA) is widely used anti-cancer drug that has to be
catalyzed by the cytochrome P450 (CYP) enzyme 2B6 as well as some other
CYPs to exert its cytotoxic activity. A high degree of interindividual
variation ...
The treatment of depression in clinical practice : a public health perspective
(2004-05-14)
been an increase in the use of antidepressant drugs, the prevalence of their reported use among depressed individuals is between 7% and 19.7%. The principal aim of this project was to investigate the evidence for the rational use of antidepressant...
Young men's sexuality and sexually transmitted infections in Zambia
(2002-10-04)
, 402 men between 16 and 26 years old have participated in the studies; 205 from Chiawa and 197 from Misisi. Random and purposive sampling techniques were used to select the men. Fifty-nine traditional healers were also included in the study. Twenty...
DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity
(2003-01-03)
The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes ...
Synthesis of heterocycles from anthranilic acid and its derivatives
(2004-05-07)
system, not a 7-membered 1,4-benzodiazepine-3,5-dione as originally claimed. Because the 1,4-benzodiazepine skeleton is highly interesting as a scaffold for development of new drugs, a few publications on synthesis of this target has appeared. However...
The transcription machinery in schizosaccharomyces pombe and its regulation
(2004-04-28)
The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the general transcription machinery. The Mediator was originally identified in Saccharomyces cerevisiae ...
Studies on sterol 27-hydroxylase (CYP27A1)
(2004-01-30)
-cholesterol was found to be converted into cholic acid and chenodeoxycholic acid considerably less efficiently than the corresponding conversion of labelled 7aOH-cholesterol. The latter oxysterol is formed in the rate-limiting sterp in the classical pathway from...
Bile in the oesophagus contributes to the development and complications of gastro-oesophageal reflux disease
(2002-05-10)
Objective: To clarify the relationship between duodenogastro- oesophageal reflux (DGOR) and gastro- oesophageal reflux disease (GORD) and its complications.
Methods: As persons who have had their gallbladders removed ...
Minimally invasive hernia surgery
(2003-04-25)
Lichtenstein (5 vs. 7 days). The time of rehabilitation was shorter after TEP than mesh-plug or Lichtenstein (14 vs. 24.5 vs. 28.5 days). There was a tendency of more pain after Lichtenstein than after TEP or mesh-plug at follow-up. Laparoscopic hernioplasty...