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Organohalogen contaminants in humans with emphasis on polybrominated diphenyl ethers
(2002-02-08)
-biphenylol (4-OH-CB 193) in adipose tissue.
The presence of PBDEs, PCBs and OH-PCBs in cord blood demonstrates that placenta is not an effective barrier for the transfer of these compounds to the foetus. consequently, infants are exposed to organohalogen...
Gene mapping of atopic dermatitis
(2001-11-14)
in 109 pedigrees forming 193 full-sib pairs and 9 half-sib pairs affected with atopic dermatitis. In total, five chromosome regions reaching the level for suggestive linkage (p<7.4x10-4) were identified. Four of these chromosome regions: 3q, 13q14, 15q14...
Atopic dermatitis : clinical and epidemiological aspects in children up to four years
(2002-05-22)
E antibodies to inhalant and food allergens was analysed at 4 years of age, and AD was divided into IgE-associated AD and nonIgE-associated.
Already during the first two years, there was a significant association not only between AD and other atopic disease...
Genetic studies of atopic dermatitis
(2001-11-22)
, using a non- parametric affected relative pair method. In the analysis 109 pedigrees were included, forming 193 affected full-sib pairs and 9 affected half-sib pairs (470 individuals). We also studied linkage and association to six chromosomal regions (2...
An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors
(2003-01-03)
The main purpose of this thesis was to examine estrogen and progestin effects of hormone replacement therapy, in relation to the risk for epithelial ovarian neoplasias. Other intentions were to assess reproductive factors, ...
Peptidergic innervation of periarticular tissue : a study in the rat
(2001-11-16)
Painful musculo-skeletal disorders pose a tremendous burden on the
healthcare system, the main reason being the limited knowledge of the
underlying pathomechanisms and lack of specific treatment.
Hypothetically, the ...
Genetic background of familial primary hyperparathyroidism
(2003-04-11)
In this thesis the aim has been to identify and characterise gene(s) involved in familial primary hyperparathyroidism (PHPT). In multiple endocrine neoplasia type 1 (MEN 1), the hyperparathyroidism-jaw tumour syndrome ...
Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes
(2002-05-15)
the restriction of TCR usage among CTL responses against a subdominat EBNA 4 derived peptide referred to as AWF. In agreement with the earlier findings, ex vivo analysis of AVF-specific CTLs using AVF-containing HLA All tetramers revealed the same degree...
Approaches for the localization and identification of human cancer genes
(2002-09-18)
Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related ...
Molecular and functional studies of interleukin-1a in the rat testis
(2002-11-15)
The aim of the present study was to gain a better insight into the role of interleukin-1 alpha (IL-1 alpha) in testicular physiology. In testis, IL-1alpha acts as a paracrine mediator involved in the regulation of testicular ...