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Pharmacokinetic studies on cladribine
(2001-11-23)
The aims of the present study were to delineate the pharmacokinetics, in plasma and leukaemia cells, of cladribine (M), and to describe factors influencing the outcome of administration of CdA in order to individualize and ...
Nitric oxide in inflammatory bowel disease
(2003-08-15)
The aim of this study was to study nitric oxide (NO) in inflammatory bowel disease (IBD) with a special reference to disease activity and disease location, in bolls an adult and a pediatric patient population, using rectal ...
Human cytomegalovirus : development of resistance to antiviral drugs and mechanisms of NK-cell evasion
(2001-09-28)
Human cytomegalovirus (HCMV), a member of the herpesviridae, is
ubiquitous and causes persistent infections mostly without any clinical
symptoms. However, HCMV infection is a major cause of morbidity and
mortality among ...
Crystallographic studies of enzymes involved in biosynthesis of fatty acids : beta-ketoacyl-acyl carrier protein synthase II and delta9-stearoyl-ACP desaturase
(2003-05-16)
In the biosynthesis of fatty acids, the beta-Ketoacyl Acyl Carrier Protein Synthases (Kas) catalyse chain elongation by the addition of two-carbon units derived from malonyl-ACP, to an acyl group bound to CoA or the small ...
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
(2003-02-14)
2*1F (-164A); CYP1A2*1J (-740G and -164A) and CYP1A2*1K (-730T, -740G and -164A) with frequencies of 39.9, 49.6, 7.5 and 3.0 %, respectively. Subjects with CYP1A2*1K had significantly decreased CYP1A2 activity in vivo (p<0.02) and reporter constructs...
Facilitation of recovery after ischaemic stroke : early dexamphetamine and physiotherapy treatment
(2003-11-28)
(p<0.01) with damph treatment compared to placebo but not the number of adverse events, or body temperature. During treatment damph improved neurological and functional outcome (p<0.05), but the differences were not maintained at follow-up. Patients...
Economic evaluation of treatments for Alzheimer's disease
(2003-11-14)
their own utility to on average 0.833 with little variation across severity levels. Proxy-rated utility ranged from 0.690 (MMSE >25), to 0.329 (MMSE<10). Proxy-rated utility, as well as changes in utilities over time, were significantly related to MMSE...
Candidate gene analyses and genome-wide screens in multiple sclerosis
(2002-11-29)
identified a C to T substitution in the IFN-gamma promoter at position -333. Screening for this mutation by sequence specific PCR in 214 MS patients and 164 controls identified two patients, both heterozygous, but no controls with this mutation. The IFN...
On transplantation of fetal ventral mesencephalon with focus on dopaminergic nerve fiber formation
(2002-04-11)
Poor cell survival and striatal reinnervation are two of the postulated limiting factors of fetal ventral mesencephalic (VM) grafting in Parkinson's disease. It has, however, been reported that an increased survival of VM ...
Langerhans cell histiocytosis : a clinical and immunological study
(2003-02-21)
-yr survival of 77% (17/22) in multi-system disease was significantly lower as compared to the 100% (27/27) survival of children who had singlesystem disease at diagnosis (p=0.014). Late sequelae of the disease or its treatment had developed in 42...