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Pharmacokinetic studies on cladribine
(2001-11-23)
H and is deglycosylated by bacterial nucleoside phosphorylases. CdA can also be cleaved, in an enzymatic reaction in the presence of the hepatic enzyme methylthioadenosine phosphorylase, to the main metabolite 2chloroadenine (CAde). A more stable fluorinated analogue...
T lymphocyte and NK cell function in pulmonary inflammation in sarcoidosis
(2003-09-19)
of activation markers on T cells bearing the T cell receptor AV2S3 in BAL fluid revealed that this T cell subset was significantly activated, expressing CD26, CD69 and HLA-DR. This finding is in line with our hypothesis that T cells with the specific T cell...
Respiratory drive assessment : an evaluation of the breath-by-breath occlusion pressure method in man
(2002-08-22)
A simplified concept of respiratory drive is to consider it as the integrated "output" from the CNS to the respiratory "pump" muscles. This drive is a result of a complex central respiratory pattern generation, and can in ...
The role of galanin in chronic pain mechanisms
(2002-11-29)
The general aim of these studies is to further elucidate the role of
galanin in pain mechanisms. We have utilized normal and genetically
modified animals and a variety of techniques. In order to use genetically
modified ...
Endothelin and nitric oxide in the fetoplacental circulation
(2004-05-21)
Background: Normal fetal growth and development depend on a satisfactory uteroplacental and fetoplacental blood flow. This will ensure an adequate gaseous exchange and nutritional supply to the fetus. The importance of ...
Functional analysis of ATM with relevance for primary immunodeficiency and tumor formation
(2004-04-08)
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by cerebellar degeneration with ataxia, ocular and cutaneous telangiectasias, radiosensitivity, chromosomal instability, immunodeficiency, and ...
Tuberculosis and HIV interaction in Ethiopian children : aspects on epidemiology, diagnosis and clinical management
(2002-08-30)
manifestations. HIV infection was negatively
associated with a positive culture (OR 0.3; 95% Cl 0.2, 0.6). Drug
sensitivity testing was done in 167 and molecular strain typing, using
the IS6110 (RFLP) and direct repeat (spoligotyping) genetic markers, in
163...
Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes
(2002-05-15)
analogues with substitutions of TCR contact residues were able to trigger cytotoxic activity without induction of IL-2 mRNA and protein or T cell proliferation. Triggering with these partial agonists in the absence of exogenous IL-2 resulted in down...
Cloning and characterization of human glutaredoxins
(2002-05-24)
disulfides.
A novel human glutaredoxin, Grx2, localized at chromosome 1 was identified and cloned. Recombinant human Grx2 exhibited GSH-dependent hydroxyethyl disulfide reductase activity (BED-assay), typical for glutaredoxins. Secondary structure...
Population-based studies of body mass index, overweight and systolic blood pressure among Swedish young men
(2002-08-30)
and overweight and systolic blood pressure in young adulthood on the other. Specific aims were to: 1) study time trends and socio-economic differences in body mass index and overweight among young men over the last decades; 2) study the occurrence of overweight...