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Survival and differentiation of central noradrenergic neurons
(2002-08-09)
was detected.
To characterize the survival requirements of developing LC neurons, we
examined the involvement of rhombomere I patterning proteins. FGF8, BMP2,
BMP5 and BMP7 were able to increase the number of TH positive LC neurons
in E13.5 LC cultures. Of all...
Cloning and characterization of a p-53-inducible gene, WIG-1
(2001-11-27)
identified by an improved differential display technique. A 7661 bp wig-1 transcript was cloned from the p53negative mouse T lymphoma cell line (J3D), transfected with a temperature-sensitive mouse mutant p53 (Val-135), using the 5 Marathon cDNA amplification...
Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system
(2002-05-17)
Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). ...
T-cell competition as a mechanism for immunodominance and the role for IL-12 in CTL responses
(2002-11-15)
Immunodominance is a process in which the immune response focuses on one
or a few of all potential epitopes that exists within an antigen. The
mechanisms for immunodominance have not yet been determined. The work
described ...
Coagulation and inflammation in experimental endotoxemia in vitro and in vivo : monitoring method and effects of nicotinamide
(2003-03-07)
In gram negative sepsis, endotoxin from the bacterial membrane elicits proinflammatory and procoagulant host responses. Sepsis and its frequent complication disseminated intravascular coagulation (DIC) are leading causes ...
Development of a novel methodology for the synthesis of oligonucleo-peptide conjugates
(2004-05-20)
Peptide-oligonucleotide conjugates constitute a new class of antisense molecules that exhibit improved biological activity over standard oligonucleotide analogues. Currently, these oligomeric bioconjugates are prepared by ...
Purification, structure and function of bioactive peptides
(2004-04-02)
. The structure was determined by mass spectrometry (MS), which identified it as insulin-like growth factor-I (IGF-I).
A novel ligand for an orphan G-protein coupled receptor, GPCR135, was detected in porcine brain extracts by guanosine 5`-O-(3-thiotriphosphate...
Long-wave ultraviolet radiation (UVA1) and visible light : therapeutic and adverse effects in human skin
(2001-09-05)
. This showed three mutations, all GgT transversion. One
of the mutations was found in codon 231 of exon 7 and the other two in
the intron. The average mutation was I per 8700 bases or 1 per 12 cells,
correlating well with the earlier findings of ultraviolet A...
Gonad development and male gametogenesis
(2002-01-25)
place, followed by female sex differentiation.
The first evidence of sexual development is the appearance of primordial germ cells (PGCs) in the early postimplantation stages of mouse development around 7 dpc. These are derived from a small population...
Molecular studies of Wig-1, a p53-induced zinc finger protein
(2003-11-14)
previously used the PCR-based differential display technique to identify mRNAs induced by wild type p53 expressed from the temperature-sensitive Val-135 mouse mutant p53 construct in J3D mouse T lymphoma cells. This system led us to the identification of a...