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Neuromechanical control of the spine
(2003-05-23)
Control of the spine is complex. The spine is inherently unstable and dependent on the contribution of muscles. Yet there is considerable redundancy in the motor system with many muscles that act on the trunk.
This ...
Children's testimony
(2002-11-26)
Background: Most cases of child sexual use are identified through statements made by children and in many cases such statements constitute the only evidence available that abuse occurred. Despite its importance the use of ...
Assignment and assessment of orthology and gene function
(2004-01-30)
Several genomes from different species have been sequenced over the last years, most notably the human genome. An important task of computational biology is to classify and functionally annotate the large amount of sequence ...
Molecular mechanisms of estrogen and antiestrogen action
(2002-11-15)
of ER alpha (HepER3 cells). The estrogenic activity is mediated through an estrogen response element (ERE) in the 5'-flanking region of the pS2 gene, however, an AP1 response element located close to the ERE in the pS2 promoter was also essential...
Molecular genetics of type 2 diabetes
(2002-04-24)
found that the incidence of diabetes in the F2 progeny significantly increased from day 31 to day 50. Four QTLs were mapped for the early development of diabetes on chromosomes 1, 2, 10, and 14 with LOD scores of 12.4, 5.1, 4.9, and 5.8. Additionally, we...
Studies of polyglutamine repeats and their biology in relation to disease
(2001-08-23)
reported. In paper 111, 41 affected individuals from five French
and one Polish FSP families linked to SPG4 were tested for expanded
CAG/CTG repeats using the RED method, PCR for the ERDA1 and CTG18.1 loci
as well as by Western blot for expressed...
Immunomodulation and immunopathogenesis in autoimmune disease with emphasis on autoimmune neuritis and arthritis
(2003-02-26)
of anti-PO peptide IgG2b antibody in serum suggested that IL-12 has a major role in the initiation, enhancement and perpetuation of pathogenic events in EAN by promoting a Th1 cell-mediated immune response and suppressing the Th2 response. These results...
O6-methylguanine-DNA-methyltransferase and DNA mismatch repair in relation to drug resistance in malignant melanoma
(2004-03-26)
polymorphisms (SNPs) in melanoma patients belonging to families with a hereditary predisposition for melanoma and healthy individuals. In total 11 SNPs were detected, 5 in the 5'-noncoding region, I in exon 1, 2 in exon 3 and 3 in exon 5. Six of the alterations...
Welander distal myopathy : gene mapping and analysis of candidate genes
(2004-03-04)
material. The Swedish WDM material consists
of 305 subjects from thirteen different families, with a total of 124
clinically affected WDM patients. Strong genetic linkage was demonstrated
to chromosome 2p13 with a maximum lod score of 17.97 for marker D2S...
A role for NK cells in innate immunity against human leishmaniasis
(2003-08-15)
Leishmaniasis is a group name for a spectrum of diseases caused by intracellular protozoa belonging to the family Leishmania. The parasites has been widely used as a tool to study the Th1 / Th2 paradigm of resistance and susceptibility in mice. A...