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The role of angiomotin in angiogenesis
(2003-12-26)
Angiogenesis plays key roles during embryonic development, female reproduction and wound repair. Angiogenesis, the formation of new blood vessels from of pre-existing capillaries, is a process tightly regulated by a balance ...
Monitoring pregnancy for improved perinatal outcome in Mozambique
(2002-11-27)
/semirural antenatal clinics in Maputo. Nine percent were lost to follow-up. This cohort was used for anthropometric monitoring of fetal growth to enable the drawing of an SFD growth chart. When selecting sub-populations, nulliparous women were found to lie 0.6 cm...
DARPP-32 in the striatum : multiple regulation and physiological role
(2001-08-24)
Protein phosphorylation is an important mechanism involved in
intracellular signal transduction. The activity of many proteins is
affected by their state of phosphorylation, which in turn is determined
by the combined ...
Antidepressive and antipsychotic treatments : effects on nerve growth factor and brain-derived neurotrophic factor in rat brain
(2002-08-30)
Recently it has been reported that depression and schizophrenia, the two major psychiatric disorders, are characterized by loss of neurons in specific brain regions. Nerve growth factor (NGF) and brain-derived neurotrophic ...
Aspects of N-glycosylation in human IgE
(2002-02-08)
The medical interest of allergy in industrialised societies has generated a much greater knowledge about the pathophysiology of IgE-mediated responses than about its normal physiological role. Because of the central role ...
Peptidergic innervation of periarticular tissue : a study in the rat
(2001-11-16)
Painful musculo-skeletal disorders pose a tremendous burden on the
healthcare system, the main reason being the limited knowledge of the
underlying pathomechanisms and lack of specific treatment.
Hypothetically, the ...
The p53-induced gene wig-1 : regulation of expression and role in embryonic development
(2003-11-21)
. Moreover, ectopically expressed wig-1 stabilized p53 protein levels and inhibition of endogenous wig-1 by siRNA reduced p53 protein in wild type p53-expressing MCF7 and HCT116 cells. In contrast, overexpression of wig-1 reduced p73 protein half...
Pheochromocytoma and abdominal paraganglioma : clinical and genetic aspects
(2001-12-28)
Pheochromocytomas and abdominal paragangliomas are rare catecholamine producing tumours arising from sympathoadrenal paraganglia located within and outside of the adrenal medulla, respectively. The great majority of tumours ...
Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans
(2003-05-16)
Gene expression in eukaryotic organisms commences with the synthesis of a precursor RNA, which has to be extensively processed to yield a mature RNA molecule. In addition to processing, the RNA molecule needs to associate ...
Studies on uptake and effect of triclosan on production of inflammatory mediators in human gingival fibroblasts
(2003-11-21)
Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is a lipid soluble anti-bacterial agent widely used in dentifrices, mouthrinses, soap and cosmetics. Although reports on the efficacy of triclosan on periodontal ...