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Effects of 1,25-dihydroxyvitamin D3 and growth hormone on osteoblast-like cells
(2003-10-03)
in osteoblasts mediated by STAT5.
In the second paper, we demonstrated that pretreatment of UMR 106 cells with 1,25(OH)2D3 prolonged GH signaling via JAK2/STAT5 pathway. Pretreatment of cells with 1,25(OH)2D3 was also necessary in order to detect GH...
Pathogenetic studies of adjuvant-induced arthritis
(2002-11-15)
of injection.
In squalene-induced arthritis the non-major histocompatibility complex (non-MHC) genetic contributions are mainly derived from two regions, the Oia2 quantitative trait locus (QTL) on rat chromosome 4 and the Oia3 QTL on rat chromosome 10...
Characterisation of eosinophil activity markers : relation to allergic inflammation and apoptosis
(2002-02-15)
. In addition, we examined the possible role of the mitochondrial membrane potential, release of cytochrome c and caspase 3 activation. When we used the apoptosis inducer tributyltin (TBT), an extremely fast induction of apoptosis was seen (measured by caspase 3...
T cell production of cytokines, neurotrophins and MHC regulation in autoimmune neuroinflammation
(2002-05-24)
study designed to investigate the neuroprotective potential of
autoimmune neuroinflammation, we employed the same rat model. Messenger
RNA expression for brain-derived neurotrophic factor (BDNF)
neurotrophin-3 (NT-3), as well as the proinflammatory...
Tobacco smoking, vascular reaction and neutrophil activity in periodontal health and disease
(2003-01-03)
Tobacco smoking has considerable negative effects on periodontal health. The mechanisms behind these effects may be related to the inflammatory response.
In this thesis, the main aim was to study the influence of ...
Direct and phagocyte-mediated lipid peroxidation of lung surfactant by group B streptococci and other bacteria : protective effect of antioxidants
(2002-09-06)
Respiratory distress syndrome (RDS), caused by surfactant deficiency, is a leading cause of mortality and morbidity in preterm neonates. Further, infants with systemic neonatal infection or pneumonia often have signs of ...
Genetic studies of susceptibility to diabetes mellitus with emphasis on type 1 diabetes
(2003-05-02)
that have been associated with T2DM.
In a genome scan of 408 Scandinavian T1DM families, I confirmed linkage of HLA (IDDM1) (p = 7 x 10-45), INS (IDDM2) (p = 10-6) and the IDDM 15 (p = 1 x 10-6) loci. Suggestive evidence of linkage was shown to chromosome...
Combined radiology and cytology in the diagnosis of bone lesions : a study of 494 patients
(2002-11-22)
diagnosed 1993 through 1998 were collected from the original reports. The study included four overlapping series: 1) 52 consecutive high grade osteosarcomas, 2) 83 consecutive myelomas/lymphomas, 3) 29 unselected lesions analysed for sample...
Functional analysis of genetic variants in putative low penetrate breast cancer genes
(2004-09-03)
carcinomas (IDC). To define the role of CDH1 in breast cancer, we used denaturing high performance liquid chromatography to screen a series of breast cancer samples for mutations. Somatic mutations were detected in 4 of 83 IDC (5%) and 3 of 25 ILC (12...
Genetic studies of atopic dermatitis
(2001-11-22)
q35, 3q21, 5q31, 6p21, 11q13, and 14q11), previously implicated as candidate regions in atopic, diseases, and one new candidate gene, the gene for Wiskott-Aldrich syndrome located on Xp 11. These candidate genes were investigated in 572 affected sib...