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The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma
(2002-05-22)
on chromosome 18 and SSX1 or SSX2 on the X
chromosome with the formation of new chimeric genes, SYT-SSX1, SYT-SSX2.
The unique chromosomal translocation t(X:18)(p11.2:q11.2) is presented in
more than 90% of the synovial sarcoma cases, and is believed...
Chlamydia trachomatis infection in Sweden : time trends, risk factors, and prevalence
(2021-02-18)
Chlamydia trachomatis (chlamydia) infection is the most common bacterial sexually transmitted infection (STI), with an estimated 127 million new cases occurring every year worldwide. Due to the asymptomatic nature of the ...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer
(2019-09-27)
Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy resistance. However...
Exosomes : the future of vaccination?
(2011-11-25)
activation was absent in Bruton kinase knockout (btk-/-) mice lacking a functional B cell compartment. Further, we found that bone marrow DC-derived exosomes express CD1d and can activate natural killer T cells (NKT cells) in vitro and in vivo. Activation...
Antibiotic use and resistance : patterns, perceptions, policy and the price to pay
(2014-05-08)
hospitals and cephalosporins in urban private hospitals. 41.1% of antibiotics were for respiratory infections. Focus group discussions (II) revealed that the public had limited awareness of infection, antibiotics and resistance and wanted quick relief...
Molecular signatures of early life exposures and complex diseases : applications using epigenetics and transcriptomics data
(2022-10-24)
enriched in cancer, various types of cell junctions, and cyclic adenosine monophosphate (cAMP) and Rap1 signaling. Notably, almost half of the CpGs co-located in the proximity of COPD-associated single nucleotide polymorphisms, which suggests that both...
Experimental spinal cord injury : methodological and neuroimmunological contributions with some historical background
(2011-01-19)
type controls, behavioral recovery and axonal regeneration were evaluated after spinal cord overhemisection. In another set of KO mice (STAT4, STAT6, IFNγ, IFNγR and IRF1) and their corresponding wild type controls inflammatory and glial cell reactions...