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Economic aspects of chronic diseases : multiple sclerosis and diabetes mellitus
(2001-11-02)
sclerosis, where the majority of resources are used
outside the health care system, a bottom-up approach is needed to capture
all resources. The total cost due to MS was calculated at 1.7 billion SEK
in 1994 using a top-down method which can. be compared...
Lipid-related genes and their associations with coronary heart disease
(2014-04-25)
Coronary heart disease (CHD) is a complex disease caused by the long-term progression of atherosclerosis. Lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and ...
Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly
(2005-12-27)
Riboflavin, also known as vitamin B2, is biosynthesized in plants, bacteria, archaea and fungi. The primary biological function of riboflavin is related to its existence as a component of the two coenzymes, flavin ...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of ...
Natural killer cells in cancer : studies on migration and cytotoxicity
(2014-05-08)
The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. ...
Interactions between neuroblastoma and the immune system : cellular pathways and mediators
(2011-03-04)
Neuroblastoma (NB) is an embryonal tumor of early childhood arising in tissues of the sympathetic nervous system, such as the adrenal gland and paraspinal ganglia. It is the most common extra-cranial solid tumor of childhood, ...
Tumor acidosis in malignant progression and therapy
(2016-04-06)
Cancer still represents one of the leading causes of death despite the advances achieved during the past years. Improving the outcome of cancer patients requires the identification of more affective therapeutic strategies ...
Exploring immunotherapeutic targets in the tumor microenvironment
(2015-11-19)
The immune system has developed along with the evolution of increasingly complex
cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental
side effect of increasing organismic complexity, ...
Adaptive immunity in urothelial cancer : molecular and clinical aspects
(2018-10-05)
In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the ...
Genetic determinants of breast cancer risk
(2011-01-19)
The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches.
In an attempt to identify common disease susceptibility alleles for breast cancer, we ...