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Gene expression in carcinogenesis
(2001-09-28)
glioma cells migrating on different matrices in vitro. In the internal experiment a novel gene, C7, was upregulated in cells migrating on laminin and was isolated and cloned. C7 is the homologue of Drosophila L82, a late puff gene and human OXR1, a gene...
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(2018-04-12)
Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway ...
Inflammatory response in periodontal tissue in children with Down syndrome
(2013-05-15)
-γ), tumour necrosis factor-α (TNF-α), and interleukin (IL)-1β, IL-4, -6, -10, -12, and -17. GCF volume (μL) was significantly higher in subjects with Down syndrome (p<0.001) than controls. Mean levels of IL-1β, IL-4, IL-6, IL-10, IL-12, IFN-γ, and TNF...
Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
(2001-05-18)
inhibited the contractions induced by LTD4, and abolished the LTE4-induced contractions. The contractions induced by LTC4 in the guinea-pig trachea and ileum were resistant to CysLT, receptor antagonism and competitively inhibited by the dual CysLT1/CysLT2...
Brain imaging in extremely preterm infants : relations to perinatal factors and outcome
(2014-01-03)
. They underwent conventional Magnetic Resonance Imaging and Diffusion Tensor Imaging at term equivalent age. Conventional T1- and T2- weighted images were visually inspected using a scoring system for white and grey matter abnormalities. Automatic segmentation...
The role of the dopamine system in the ability of (-)-OSU6162 to reduce voluntary alcohol drinking and binge-eating in the rat
(2017-11-22)
BACKGROUND AND AIMS: The dopamine system is involved in the reinforcing effects of both food and alcohol and is thus a potential treatment target for alcohol use disorder (AUD) and binge-eating disorder (BED). Alcohol use ...
Role of the OX40 ligand/receptor pair in coronary artery disease
(2006-11-17)
genes in a human context. This strategy applied to strains susceptible to diet-induced atherosclerosis (C57BL/6) identified 0x401 as the gene underlying the atherosclerosis-susceptibility locus Ath1 on chromosome 1. 0x401 was shown to control lesion...
Clinical studies of hemophagocytic lymphohistiocytosis
(2011-11-07)
Background and aims: The term hemophagocytic lymphohistiocytosis (HLH) comprises two main disease entities: the primary, familial form (FHL) and an acquired, secondary form (sHLH). FHL is autosomal recessive in inheritance, ...
On gender dysphoria
(2017-03-10)
Gender identity refers to an innate and deeply felt psychological identification as a female, male, or some other non-binary gender. Gender identity may be congruent or incongruent with the sex assigned at birth. Gender ...
Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients
(2007-02-22)
In spite of the promising results shown by new anti-myeloma agents,
multiple myeloma (MM) remains incurable and additional therapy to
overcome the inevitable disease recurrence is greatly needed.
Immunotherapy is currently ...