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Hereditary breast/ovarian cancer : implementation of BRCA1 and BRCA2 testing
(2001-05-02)
Breast cancer is the most common malignancy among women in the western
world. Most cases are sporadic but in 5 to 10 % an inherited genetic
mutation is the main cause of the disease. Families with inherited breast
cancer ...
Craniofacial development after three different palatoplasties in children born with isolated cleft palate
(2018-11-14)
Introduction: Different palatoplasties are applied for the surgical correction of children born with an isolated cleft in the palate (ICP). During the last decades the Veau-Wardill-Kilner (VWK), Minimal Incision (MI) and ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Cardiovascular disease risk among people living with HIV in South Central Uganda
(2022-10-21)
Background: With the introduction of effective antiretroviral therapy (ART), the clinical management needs of people living with HIV are rapidly shifting from AIDS-related opportunistic infections to age-related co-morbidities. ...
Regulatory networks of c-di-GMP signalling involved in biofilm formation, motility and host pathogen interactions in Salmonella typhimurium
(2013-08-09)
Adaptation to altered environmental conditions is one of the fundamental bacterial characteristics. The ubiquitous second messenger c-di-GMP plays a key role to adopt bacterial behaviour. Transition from motility to sessility ...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...
Adaptation of Salmonella enterica to antibiotics and innate immunity effectors
(2021-02-22)
Salmonella enterica is a bacterial pathogen causing major morbidity and mortality in low- and middle-income countries. The bacteria can cause a wide range of disease, ranging from the severe systemic disease typhoid fever ...
Regulation of biofilm formation in Salmonella typhimurium and Escherichia coli Nissle 1917
(2010-12-20)
Bacteria have the ability to grow in cell communities designated biofilms. This mode of growth is widespread and offers numerous advantages to the bacteria in terms of survival, persistence and propagation. Bacteria have ...
Are we using antibiotics responsibly? Assessing antibiotic use in rural Shandong province, China
(2020-02-19)
Background: Tackling the misuse and overuse of antibiotics is critical both for global sustainable development and for reducing social inequalities in the world. The World Health Organisation Global Action Plan on antimicrobial ...