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Molecular monitoring of engraftment and leukemia relapse after allogeneic hematopoietic stem cell transplantation
(2001-05-18)
, relapsed. In contrast, none of the seven patients with donor chimerism (DC) relapsed (p=0.01).Mixed chimerism was detected between 2.5 and 4 months before over trelapse in three patients who relapsed. In all five patients with MC in the B-cell lineage...
Molecular monitoring of engraftment and leukemia relapse after allogeneic hematopoietic stem cell transplantation
(2001-05-18)
. In contrast, none of the seven patients with donor chimerism (DC) relapsed (p=0.01). Mixed chimerism was detected between 2.5 and 4 months before over trelapse in three patients who relapsed. In all five patients with MC in the B-cell lineage, the leukemia...
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage
(2021-02-17)
A family of multipotent heart progenitors plays a central role in the generation of diverse myogenic and nonmyogenic lineages in the heart. Cardiac progenitors in particular play a significant role in lineages involved in ...
Genetic studies of congenital upper limb anomalies
(2014-03-03)
The overall aim of the work reported in this thesis is to improve epidemiological and genetic knowledge of congenital upper limb anomalies (CULA). To accomplish the specific aims of each paper several different methods and ...
Heart rate variability in patients with stable angina pectoris
(2009-01-16)
The rate and modulation of the heart beat (i.e. heart rate variability; HRV) are controlled by the autonomic nervous system. Cardiac sympathetic activation decreases and parasympathetic increases HRV. Measurements of HRV ...
Long-term exposure to air pollution from road traffic and development of airway and allergic diseases in children
(2012-11-22)
years of age. Risks appeared particularly elevated in children aged 8-12 years (OR, 2.0; 95% CI, 1.1–3.5) and for nonallergic asthma (3.8; 0.9–16.2), for a 7.2 μg/m3 increase in PM10. Furthermore, early-life exposure to air pollution seemed to have long...
Blood donors' long-term health : implications for transfusion safety
(2007-11-12)
Continuous attention to transfusion safety through improvement of disease
screening and donor selection has succeeded in reducing the risks of
transfusion transmitted disease to practically immeasurable levels.
Despite ...
PET studies of the serotonin system in major depression and its treatment
(2014-10-03)
The serotonin system has been implicated in major depression since the
1960s, mainly based on the serotonin enhancing properties of
antidepressants. Positron emission tomography, PET, is the in vivo
molecular imaging ...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ...
Ultrasound assessment and risk prediction in women with endometrial cancer
(2020-01-09)
Background: Endometrial cancer is the most common gynecological cancer in the industrialized world, constituting 4.5% of all cancer in Swedish women. Standard surgery is hysterectomy and bilateral salpingo-oophorectomy, ...