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Luminal nitric oxide : marker of intestinal inflammation
(2001-04-06)
Nitric oxide (NO) is a pluripotent molecule with several important
physiological functions in the human body. Large amounts of NO are
released by various cell types during inflammation, although the role of
NO in the ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
Rapid advances in molecular and cellular biology have improved the understanding of the mechanisms involved in leukemia development. Cyclin-dependent kinases (CDKs) and matrix metalloproteinases (MMPs) have been suggested ...
Cytoskeleton-interacting proteins in brainstem development : roles of KCC2 and Vangl2
(2010-12-21)
structural interaction with the cytoskeleton-associated protein 4.1N. Thus, transport-inactive KCC2 may regulate neuronal differentiation and migration during early development. We assessed the early importance of KCC2 further in mice knockout for this gene...
Conserved structure-function relationships in the mediator complex
(2007-02-16)
sensitive allele srb4-138. We found that the srb4-138 allele disrupts the interaction between the head and middle domains both in vitro and in vivo. This suggested that the global shutdown of transcription in srb4-138 cells at the non-permissive temperature...
Immunoregulatory effects of placenta-derived decidual stromal cells
(2016-01-08)
DSC treatment. Increased plasma concentrations of IL-6, IL-8, and IP-10 distinctly differentiated the non-responders from the responders before DSC intervention. Although the expression of HLA-DR decreased over time in the CD4+ compartment...
Studies on meniscus surgery with focus on preservation and meniscus function
(2020-12-23)
The aim of this thesis was to investigate the effect of surgical preservation and restoration of the meniscus on knee function and outcomes. In Study I, 4497 patients with primary hamstring ACLR were evaluated regarding ...
On biomarkers in traumatic brain injury
(2015-04-29)
Traumatic brain injury (TBI) is a common cause of death and disability. Unfortunately, TBI patients will be affected by secondary insults, such as hypoxia and increased intracranial pressure, which may lead to secondary ...