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Galanin : a modulator of serotonin neurotransmission : relevance for depression
(2001-03-02)
Galanin is widely distributed throughout the central nervous
system with multiple and diverse biological roles. In the rat,
galanin-like immunoreactivity is expressed in a population
of5-hydroxytryptamine (5-HT, serotonin) ...
Observations on essential biochemical data profile in connection with restorative proctocolectomy in humans : vitamin B12 and fat absorption cited
(2001-10-18)
PATIENTS: The material includes 99 patients who consecutively received
handsawn pouch and ileoanal anastomosis, after mucosectomy. Sixty-five
patients were men and forty-four were women. The mean-age was 31.4 (range
17-59) ...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of ...
Neutrophil interactions with Streptococcus pyogenes and Staphylococcus aureus
(2017-04-03)
Streptococcus pyogenes and Staphylococcus aureus are Gram-positive bacteria that share many features, including clinical presentations and pathogenic mechanisms, and yet, they still have unique properties. They both cause ...
Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology
(2022-10-21)
with high affinity CD16 to improve ADCC against autologous tumor biopsies. In paper IV, we applied biological insights from a genetic condition where patients carrying a mutation in the CXCR4 chemokine receptor suffer from lymphocytes being retained...
Prognostic factors in breast cancer with a focus on the role of tumour proliferation
(2018-01-26)
Ki67 is the most commonly used marker of proliferation in breast cancer. The general aim of the thesis was to investigate the prognostic role of Ki67 and its interplay with other prognostic factors in breast cancer ...
Genetic determinants of breast cancer risk
(2011-01-19)
The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches.
In an attempt to identify common disease susceptibility alleles for breast cancer, we ...
Living with violence in the home : exposure and experiences among married women, residing in urban Karachi, Pakistan
(2011-11-25)
AIM: A study was conducted in urban Karachi, Pakistan to investigate prevalence, frequency, risk factors, and mental health effects of husbands’ violence against their wife. It also explores current gender roles in urban ...
Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment
(2022-01-27)
the principles of NK cell-mediated cancer immunosurveillance, and provides an overview on rare cancers, mainly focusing on sarcoma. The research aims are listed in Chapter 3. In Chapter 4, I describe the cell culture methods and cell analysis techniques relevant...
Novel markers for smooth muscle cell modulation in vascular injury and disease
(2022-08-02)
Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during ...