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Vascular functions in infants, children and their mothers
(2001-03-02)
hyperemia, measured with a laser Doppler instrument, did not change significantly between 2 and 24 h of postnatal age. The overall degree of reactive hyperemia was 69 (0 - 458) % in excess of basal perfusion and time to postocclusive peak perfusion was 4.6...
Regulation of neurotrophins and their receptors : molecular aspects and functional implications
(1997-05-16)
The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using ...
Regulation of Plasmodium falciparum virulence genes and immune response to surface antigens in placental malaria
(2011-11-15)
Malaria infection caused by the parasite Plasmodium falciparum is a deadly torment, especially for young children and pregnant women residing in sub-Saharan Africa. Much of the parasites virulence is due to its ability to ...
Small molecules as research tools for studying the biology of the tumour suppressor p53
(2011-05-24)
p53 is a potent tumour suppressor that is inactivated in the majority, if not all human
cancers. In about 50% of the cases, the gene is mutated and in the rest it is rendered
inactive mainly by deregulation of its ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
Oxygen is essential for all respirating life forms. However, the use of molecular oxygen as terminal electron acceptor of the respiratory electron chain leads to the generation of reactive oxygen species (ROS) as product ...
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
(2020-03-17)
The research focus of this thesis is polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, associated with reproductive, cardio-metabolic, and mental health complications. ...
Intrauterine immunology in allergy and infection
(2009-01-02)
Pregnancy is interesting from an immunological point of view. The maternal immune system has to tolerate the fetus and at the same time also protect against infection. The placenta is not a completely tight barrier: in ...
On antidepressant effects of running and SSRI : focus on hippocampus and striatal dopamine pathways
(2007-05-25)
Considering the heterogeneous character of depression, it seems likely
that many brain regions are involved mediating the diverse symptoms of
depression. For example, the mesolimbic DA system has a central function
for ...
Immunological changes in human blood and skeletal muscle in response to physical exercise
(2001-09-21)
Physical exercise is essential for maintaining normal function of skeletal muscle. Muscle tissue also has a remarkable capacity for adaptation to changes in physical demand. In fact, without stimulation from physical ...
The role of SOXC transcription factors in B-cell development and lymphoid malignancies
(2017-09-15)
Mantle cell lymphoma (MCL) accounts for 5-10% out of all Non-Hodgkin lymphomas (NHLs) and is one of the most aggressive forms of lymphomas with a median survival of less than 5 years. Currently, MCL is considered to be an ...