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Physiology and pathophysiology of central adenosine A1 and A2A receptors
(2003-05-23)
The aim of this thesis was to further investigate the individual roles of central adenosine A1 and A2A receptors in the physiological and pathophysiological effects of adenosine. In addition, the characteristics of different ...
Helicobacter pylori infection among children in Sweden
(2001-04-06)
Since Helicobacter pylori was first identified in 1983 convincing data has linked the infection to the development of gastritis and peptic ulcer disease and H. pylori has further been implicated in gastric carcinogenesis. ...
Measurements for improvement of running capacity : physiological and biomechanical evaluations
(2009-10-09)
Introduction: Running is included in a large number of sports and one of the most well investigated modes of locomotion in both physiology and biomechanics. This thesis focuses on how some new methods from both areas may ...
Understanding inflammatory mechanisms in rheumatic diseases
(2014-11-05)
Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ...
Diet and risk of acute pancreatitis
(2016-05-11)
Acute pancreatitis is a sudden inflammation of the pancreas. It has a broad spectrum of clinical outcomes, ranging from mild and self-limiting to severe and potentially fatal, and is often followed by recurrent attacks ...
Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
(2009-10-30)
, glomerulonephritis and inflammatory diseases. (R)-roscovitine (Rosco) is a synthetic tri-substituted purine that inhibits selectively Cdk1, 2, 5, 7 and 9. Rosco has shown promising cytotoxicity in cell lines and tumor xenografts. Rosco so far has only demonstrated...
Interleukin-22 binding protein in multiple sclerosis and experimental inflammation models
(2017-10-20)
Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults. Although the cause of the disease is unknown, several genetic and environmental risk factors have been identified. By ...
Novel approaches for cancer immunotherapy
(2008-05-22)
-TAMs can be also modified using zoledronic acid (ZA). We show that ZA suppresses the expression of MMP-9 by TAMs and, in combination with IL-12, enhances their tumor-eliminating functions. Furthermore, ZA drives the proliferation and activation of gamma...
Factors affecting growth, differentiation and apoptosis of osteoblastic and osteosarcoma cells
(2008-10-17)
Osteoblasts play a fundamental role in determining bone structure and function. These cells originate from mesenchymal stem cells (MSCs) and through proliferation and differentiation develop into preosteoblasts and then ...
Studies on meniscus surgery with focus on preservation and meniscus function
(2020-12-23)
The aim of this thesis was to investigate the effect of surgical preservation and restoration of the meniscus on knee function and outcomes. In Study I, 4497 patients with primary hamstring ACLR were evaluated regarding ...