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Diagnostic considerations on whiplash associated disorders
(1998-09-11)
the accident 350 - 400 (i.e., 3.5 - 4 %) still have symptoms. They will be given the diagnosis of WAD. The aims of the study were: 1) to develop and evaluate an objective test to diagnose WAD; 2) to perform an otoneurologic examination of a series of patients...
Effects of alcohol consumption on health and mortality
(2001-01-26)
During the last 25 years, alcohol consumption has become a widely debated issue, especially due to research results, in which the beneficial effects of alcohol on health and mortality have been maintained. Research has ...
Effects of alcohol consumption on health and mortality
(2001-01-26)
During the last 25 years, alcohol consumption has become a widely debated issue, especially due to research results, in which the beneficial effects of alcohol on health and mortality have been maintained. Research has ...
Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
(2012-11-22)
Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of ...
Breast cancer natural history models and risk prediction in mammography screening cohorts
(2022-03-31)
In this thesis, the foundations are laid for a new natural history model for breast cancer—specifically designed to take advantage of detailed screening cohorts. Three diverse applications of this model are then presented. ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine ...
Depression and cardiovascular diseases
(2018-09-28)
included. Depression was assessed using the Major Depression Inventory (MDI). Severity of depression was assessed using MDI and additionally measuring anxious distress according to DSM-5 (paper I). Neuroticism was assessed by the Swedish Scale...
Expression of inflammatory and insulin signaling genes in acute and chronic stress
(2010-05-17)
on abdominal subcutaneous adipose tissue. Gene expression levels were compared between CKD stage 5 patients and non-uremic controls to reveal uremic specific alterations. In accordance with surgical patients, adipose tissue from CKD patients showed a...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
of escitalopram (5 mg twice daily for a week), we noted a trend towards a 21% lower exposure in CYP2C19*17 homozygous individuals. However, this did not reach statistical significance in this study that was powered for a 40% difference. The clinical impact (or...
Genetic determinants of breast cancer risk
(2011-01-19)
The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches.
In an attempt to identify common disease susceptibility alleles for breast cancer, we ...