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Glucosyltransferase toxins from clostridia : molecular interactions with cells
(2000-11-27)
An enzymatic activity was recently described for the group of Large Clostridial Cytotoxins (LCTs). This activity is glucosyltransfer and consists in the covalent addition of glucose, from UDP-glucose (UDP-Glc) to threonine ...
Immunopathology and signalling molecules involved during experimental African trypanosomiasis
(2000-09-21)
In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. rhodiense. Trypanosomes are transmitted by ...
HIV-2 and SIV vaccine studies in macaques : with emphasis on humoral immune responses
(2001-04-12)
This thesis describes the evaluation of HIV vaccines candidates in the
HIV-2 or SIV monkey models. The immunogenicity and protective efficacy of
the vaccines were investigated. Furthermore, correlates to protective
immunity ...
Self-reported fecal incontinence and quality of life among gynecological cancer survivors
(2010-05-07)
Gastrointestinal symptoms following pelvic radiotherapy are common;
however, selfreported descriptions of gastrointestinal symptoms and their
impact on daily life among gynecological cancer survivors are rare in ...
Periodontitis and invasive oral treatment in relation to myocardial infarction : epidemiological studies
(2019-11-25)
Background: Cardiovascular disease and periodontitis are major global health problems that are a large burden for the individual and society. During the last 30 years, it has been discussed whether there is an association ...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
of dexamethasone-induced growth retardation. By investigating these mechanisms, we found that dexamethasone activates caspase-8, -9 and -3 in proliferative chondrocytes. In addition, the Akt-PI3K signaling pathway, which plays a key role in the survival...
Long term effects of lumbar disc herniation surgery in adolescents
(2020-05-08)
Background: In Sweden, about 2,900 surgeries due to a lumbar disc herniation are performed yearly, and the surgical incidence is low compared to the incidence in Denmark and Norway. Surgery for lumbar disc herniation in ...
Studies on the inflammatory response in experimental acute pyelonephritis and its importance for the development of renal scarring
(2002-01-08)
antagonist, losartan, the same experimental model was used. Mice treated with losartan showed a marked reduction of TGF-beta mRNA expression and protein secretion compared to saline treated controls. A 50% reduction in cortical scarring was also observed at 3...
Diagnosis and treatment of Helicobacter pylori infection in Vietnamese children
(2009-11-20)
children (age 3-15 years) for various gastrointestinal complaints. H. pylori infection status was based on either positive culture or positive monoclonal antigen-in-stool test (Premier Platinum HpSA PLUS) at inclusion and positive monoclonal antigen...
TRIM21/ Ro52 in B cell pathology
(2013-01-25)
was initiated. However, TRIM21 had been implicated to belong to the TRIpartite Motif (TRIM) family, of which many proteins are E3 ligases, mediating ubiqiutination. The aims of this thesis were to characterize the role of B cells in primary Sjögren’s syndrome...