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Studies of the recognition and activation of natural killer cells
(2000-11-23)
Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other ...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, ...
Characterisation of human fetal mesenchymal stem cells
(2004-11-26)
Mesenchymal stem cells (MSCs) are present in various tissues of fetal and adult origin. I isolated and expanded MSCs from human fetal 1st trimester livers and observed that they have a shorter cell doubling time compared ...
Mitochondria targeting and its consequences for cell death in neuroblastoma
(2018-12-14)
Mitochondria are one of the central regulators of several physiological and pathological processes. For instance, homeostatic glycolysis, citric acid cycle, and oxidative phosphorylation are all regulated by mitochondria. ...
Mechanisms of malignant and non-malignant angiogenesis using zebrafish models
(2010-10-01)
Pathological angiogenesis significantly contribute to the onset, development and progression of most common and severe human diseases including cancer, metastatic disease, cardiovascular disease, age-related macular ...
The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?
(2014-03-07)
In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in ...
Psychological distress and breast cancer : a bidirectional link
(2022-11-09)
Psychological distress is one of the six vital signs among patients with cancer. An increased risk of psychiatric disorders has also been reported among cancer patients, compared with the general population. On the other ...
The pathophysiological roles of kynurenic acid and cytokines in psychiatric illness
(2011-09-07)
Kynurenic acid is an astrocyte-derived tryptophan metabolite and a marker of neuroinflammation that antagonizes N-metyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors in the brain. Increased levels have been ...